蕈样肉芽肿早期诊断的进展  

Recent advances in mycosis fungoides early diagnosis

作　　者：张雨微 郭书萍[2] 张乐 ZHANG Yuwei;GUO Shuping;ZHANG Le(The First Clinical College,Shanxi Medical University,Taiyuan,Shanxi 030000,China;Department of Dermatology,the First Hospital of Shanxi Medical University,Taiyuan,Shanxi 030000,China)

机构地区：[1]山西医科大学第一临床医学院,山西太原030000 [2]山西医科大学第一医院皮肤科,山西太原030000

出　　处：《安徽医药》2023年第5期859-863,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：蕈样肉芽肿(MF)是最常见的原发皮肤T细胞淋巴瘤,临床表现多样,且早期皮损组织病理缺乏特异性,因此早期诊断较为困难,往往导致漏诊或误诊,严重影响病人的预后。现对近年来国内外关于MF皮肤组织病理、免疫组化、T细胞基因重排检测方法、早期诊断算法、微RNA(MicroRNA)以及皮肤影像学等研究进展进行总结,以便及早诊断,及时治疗,改善预后。Mycosis fungoides(MF) is the most common type primary cutaneous T-cell lymphoma.Diagnosis of MF can be difficult due to highly variable presentations and the sometimes nonspecific nature of histological findings in early stage.It often lead to missed diagnosis and to misdiagnosis,which have serious consequences.This review summarizes the recent research progress of MF's histopathology,immunohistochemistry,T cell gene rearrangement detection method,early diagnosis algorithm,MicroRNA and skin imaging at home and abroad,which have benefits for patients in terms of earlier-stage diagnosis,offerd timely treatment and improved quality of life.

关 键 词：淋巴瘤 T细胞 皮肤 蕈样肉芽肿 诊断 组织病理 免疫组化 

分 类 号：R739.5[医药卫生—肿瘤]