高分辨质谱在食品农药残留检测中的研究进展  

Research Progress on Detection of Pesticide Residues in Food by High-resolution Mass Spectrometry

作　　者：张申平 周静[1] 杜茹芸 郑翌[1] 刘洋[1] 徐红斌[1] ZHANG Shen-ping;ZHOU Jing*;DU Ru-yun;ZHENG Yi;LIU Yang;XU Hong-bin(Shanghai Institute of Quality Inspection and Technical Research/Key Laboratory of Milk and Dairy Products Detection and Monitoring Technology for State Market Regulation,Shanghai 200233,China)

机构地区：[1]上海市质量监督检验技术研究院/国家市场监管重点实验室(乳及乳制品检测与监控技术),上海200233

出　　处：《分析测试学报》2023年第4期502-509,共8页Journal of Instrumental Analysis

基　　金：国家市场监督管理总局科技计划项目(2021MK035)。

摘　　要：利用准确、可靠的色谱-质谱联用分析技术开展我国食用农产品中农兽药残留、有机污染物等有害物质的筛查和检测具有重要意义。高分辨质谱具备更高的分辨率和质量精度,在复杂食品基质中痕量化合物的定性确证和定量检测方面拥有很大应用潜力。该文综述了四极杆/飞行时间质谱(Q/TOF MS)、四极杆/静电场轨道阱质谱(Q/Orbitrap MS)技术的特点,重点分析了2017年至2022年国内外植物源和动物源食品中农药残留检测的高分辨质谱应用情况。从高分辨质谱技术本身的发展、食品安全监管部门和第三方检测机构的技术需求3个方面讨论了高分辨质谱技术的发展前景,展望了其未来研究的主要方向。It is of great significance to use accurate and reliable chromatography-mass spectrometry to screen and detect residues of pesticides,veterinary drugs,organic pollutants and other harmful substances in edible agricultural products.High-resolution mass spectrometry(HRMS)has higher resolution and accuracy quality in qualitative and quantitative detection on trace compounds in the complex food matrix.The technical characteristics of quadrupole/time-of-flight mass spectrometry(Q/TOF MS)and quadrupole/orbitrap mass spectrometry(Q/Orbitrap MS)are reviewed in this paper,and the applications of HRMS in detection of pesticide residues in plant and animal derived food at home and abroad from 2017 to 2022 are focused on.The development prospect of HRMS technology is discussed from three aspects,i.e.the development of HRMS technology,the technical require⁃ments of food safety supervision departments and the third party testing institutions.In conclusion,chromatography-mass spectrometry has become the mainstream technology adopted in the national food safety standards in China since the early 21st century.The development and improvement of nanoflow-chromatography,heated dual ion source(DUIS)and other technologies are expected to im⁃prove the sensitivity of HRMS.The HRMS screening combined with triple quadrupole mass spec⁃trometry confirmation technology,application and standardization of HRMS methods are the main di⁃rections for future research.

关 键 词：高分辨质谱(HRMS) 食品 农药残留 高通量检测 

分 类 号：O657.63[理学—分析化学] TS207.3[理学—化学]