干细胞样CD8^(+)T细胞在抗肿瘤免疫治疗中的地位与演进效应  

Role and mechanism of action of stem-like CD8^(+)T cells in anti-tumor immunotherapy

作　　者：林果 姚卓然 王徽 纳飞飞(综述)[1] 卢铀(审校)[1] Guo Lin;Zhuoran Yao;Hui Wang;Feifei Na;You Lu(Thoracic Oncology Ward,Department of Radiotherapy,Cancer Center,West China Hospital,Sichuan University,Cancer Center,Laboratory of Clinical Cell Therapy,Chengdu 610041,China)

机构地区：[1]四川大学华西医院肿瘤中心胸部肿瘤病房,放疗科,四川大学华西医院临床细胞治疗研究室,成都市610041

出　　处：《中国肿瘤临床》2023年第7期373-376,共4页Chinese Journal of Clinical Oncology

基　　金：四川大学华西医院学科卓越发展1·3·5工程项目(编号:ZYJC21003)资助

摘　　要：以抗细胞程序性死亡-1/细胞程序性死亡-配体1(programmed cell death-1/programmed cell death-ligand 1,PD-1/PD-L1)为代表的免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)治疗显现了CD8+T细胞在治疗和可能治愈恶性肿瘤方面的潜力。但仅约20%的患者对ICIs治疗获益,因此阐明CD8+T细胞在免疫微环境中的有效抗肿瘤功能,及其分子和空间的决定因素尤为重要。具有自我更新、增殖分化和杀伤肿瘤细胞能力的干细胞样CD8^(+)T细胞亚群,在介导抗肿瘤免疫效应方面扮演极为重要的角色。本文就干细胞样CD8^(+)T细胞在抗肿瘤免疫循环中的地位与演进效应进行综述。Anti-programmed cell death-1/programmed cell death-ligand 1(PD-1/PD-L1)as immune checkpoint inhibitors(ICIs)therapy has shown the potential of CD8+T cells in treating and possibly curing malignancies.However,only approximately 20%of patients benefit from ICI therapy.Therefore,it is necessary to elucidate the antitumor function of CD8+T cells in the immune microenvironment and its molecular and spatial mechanism of action.Stem-like CD8^(+)T-cell subsets with the ability of self-renewal,proliferation,differentiation,and killing of tumor cells play a vital role in mediating anti-tumor effects.In this review,we analyzed the roles and evolutionary effects of stem-like CD8^(+)T cells in anti-tumor effects.

关 键 词：干细胞样 CD8^(+)T 淋巴细胞 免疫治疗 肿瘤微环境 

分 类 号：R730.51[医药卫生—肿瘤]