生物节律紊乱与免疫炎症相互作用在抑郁症发病及治疗中作用研究进展  

Research progress on the interaction between biological rhythm disturbance and immune inflammation in depressive disorder

作　　者：魏喆懿 王凡[1] 黄秦特 徐初琛[1] 张梦珂 石书香 洪武[1,2] WEI Zheyi;WANG Fan;HUANG Qinte;XU Chuchen;ZHANG Mengke;SHI Shuxiang;HONG Wu(Shanghai Mental Health Center,Shanghai 200032,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200032 [2]上海市重性精神病重点实验室

出　　处：《中国神经精神疾病杂志》2023年第2期125-128,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：上海市“科技创新行动计划”医学创新研究专项(编号:21Y11905600);上海市“科技创新行动计划”自然科学基金项目(编号:21ZR1455100);上海市交通大学医学院科技创新项目(人文社科类)(编号:WK2017)。

摘　　要：抑郁症的发生发展机制尚未明确,生物节律与免疫炎症都与其相关,同时,生物节律与免疫炎症存在互相影响,因此二者之间的交互作用或许是抑郁症的致病环节之一。本文从临床表现、生物学机制和治疗应用三个方面总结了目前生物节律和免疫炎症交互作用在抑郁症发病中的角色,发现它们与不同的症状和疗效相关,可以根据患者的炎症水平和生物节律选择相应的治疗方法,这种交互作用对抑郁症患者的个体精准化治疗有潜在价值。The cause and development of major depressive disorder(MDD)are not clear yet.Both circadian and inflammation are thought to be related to it,and at the same time,circadian system and inflammation also interact with each other.Therefore,the bidirectional relationships between them may be one of the key pathogenic links of MDD.In this review,the way they interact each other,the potential biological mechanism and therapy in MDD are critically summarized.Clarifying the role of their relationship in MDD is crucial for potentially valuable therapies and future research in the related domain.

关 键 词：抑郁症 生物节律 炎症 抑郁症状 褪黑素 睡眠剥夺 光照治疗 

分 类 号：R749.4[医药卫生—神经病学与精神病学]