姜黄素抗纤维化作用在眼科中的研究进展  

Research progress of antifibrotic effect of curcumin in ophthalmology

作　　者：曹莉[1,2] 蔡岩 CAO Li;CAI Yan(The Shihezi University School of Medicine,Shihezi 832002,China)

机构地区：[1]石河子大学医学院,石河子832002 [2]新疆军区总医院,乌鲁木齐830099

出　　处：《中国中医眼科杂志》2023年第4期383-387,共5页China Journal of Chinese Ophthalmology

基　　金：乌鲁木齐市卫生健康委员会科技计划项目(202141)。

摘　　要：姜黄素是我国传统中药姜黄、咖喱、郁金、藤黄、肉桂等的有效成分,具有广泛的抗纤维化作用而无明显毒副作用。本文概括了姜黄素抗纤维化作用的主要机制,包括抑制转化生长因子-β(TGF-β)信号转导通路、清除活性氧(ROS)、抑制炎症因子,同时总结了姜黄素抗纤维化作用在眼科研究中的应用,包括翼状胬肉、青光眼术后滤过通道瘢痕化、后发性白内障(PCO)和增生性玻璃体视网膜病变(PVR)、角膜瘢痕,为姜黄素抗纤维化作用在眼科中的进一步研究提供参考。Curcumin is an effective component of Traditional Chinese Medicine such as turmeric,curry,turmeric vine,cinnamon,etc.,with a wide range of anti-fibrotic effects and no significant toxic side effects.This paper summarizes the main mechanisms of curcumin's anti-fibrosis effects,including inhibition of the transforming growth factor-β(TGF-β)signaling pathway,clearance of reactive oxygen species(ROS),and suppression of inflammatory factors.Additionally,it summarizes the application of curcumin's anti-fibrotic effects in ophthalmology research,including pterygium,postoperative trabecular meshwork scarring in glaucoma,posterior capsular opacification(PCO),proliferative vitreoretinopathy(PVR),and corneal scarring,providing a reference for further research on curcumin's anti-fibrotic effects in ophthalmology.

关 键 词：姜黄素 纤维化 翼状胬肉 青光眼滤过术 后发性白内障 增生性玻璃体视网膜病变 角膜瘢痕 

分 类 号：R771[医药卫生—眼科]