近红外光谱分析技术在无创监测脑自主调节功能中的应用  

Application of near-infrared spectroscopy in noninvasive monitoring of cerebral autoregulation function

作　　者：任昱洁(综述) 彭玲(审校)[2] REN Yujie;PENG Ling(Department of Anesthesia,West China Hospital,Sichuan University/West China Medical School of Sichuan University,Chengdu,Sichuan 610044,China;Department of Anesthesiology,West China Hospital,Sichuan University,Chengdu,Sichuan 610044,China)

机构地区：[1]四川大学华西医院麻醉科/四川大学华西临床医学院,四川成都610044 [2]四川大学华西医院麻醉科,四川成都610044

出　　处：《现代医药卫生》2023年第7期1211-1217,共7页Journal of Modern Medicine & Health

基　　金：国家自然科学基金面上基金项目(81971772)。

摘　　要：脑自主调节功能(CA)与脑血流量、颅内压、血压等关键临床参数密切相关,CA的评估与监测在脑血管疾病、创伤性脑损伤、手术、新生儿等领域中均具有重要意义。现有的CA评估技术包括热稀释法、指示剂稀释法、CT血管造影、磁共振血管造影等侵入性手段,以及正电子发射断层扫描、经颅多普勒超声、近红外光谱(NIRS)分析技术等无创监测方法。然而侵入性监测技术、正电子发射断层扫描、经颅多普勒超声等技术由于有创、操作复杂或费用高昂等弊端在临床实际工作中应用受限。NIRS具有无创、便捷、经济且可定量等诸多优势,为临床实际工作中CA的评估带来了极大的便利,具有良好的应用前景。该文综述了NIRS技术在CA监测与评估中的应用、临床意义、准确性、局限性、发展前景等。Cerebral autoregulation(CA)function is closely related to key clinical parameters such as cerebral blood flow(CBF),intracranial pressure(ICP)and blood pressure,etc.The evaluation and monitoring of CA function are important in the fields of cerebrovascular disease,traumatic brain injury,surgery,neonatology and so on.The existing CA evaluation techniques include thermal dilution,indicator dilution,computed tomography(CT)angiography,magnetic resonance angiography and other invasive methods,as well as noninvasive monitoring methods such as positron emission tomography,transcranial Doppler ultrasound,and near-infrared spectroscopy(NIRS).However,invasive methods,positron emission tomography,and transcranial Doppler ultrasound are limited in practical clinical application due to drawbacks like invasiveness,complexity of operation,or high cost.NIRS has many advantages such as being noninvasive,convenient,economical and quantifiable,which has brought great convenience to the evaluation of CA in clinical practice and has great application prospects.This article reviewed the application,clinical significance,accuracy,limitations and development prospects of NIRS technology in CA monitoring and evaluation.

关 键 词：脑自主调节功能 近红外光谱 总血红蛋白反应性指数 脑血氧饱和度指数 脑血管疾病 创伤性脑损伤 综述 

分 类 号：R741[医药卫生—神经病学与精神病学]