Double-edged roles of IFNγ in tumor elimination and immune escape  

作　　者：Yueyue Chen Ningning Niu Jing Xue 

机构地区：[1]State Key Laboratory of Oncogenes and Related Genes,Stem Cell Research Center,Shanghai Cancer Institute,Ren Ji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China

出　　处：《Journal of Pancreatology》2023年第1期8-17,共10页胰腺病学杂志（英文）

基　　金：National Natural Science Foundation of China(No. 82022049, JX;No. 82073105, NN);Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(No. 20161312, JX);State Key Laboratory of Oncogenes and Related Genes(KF2113, NN)。

摘　　要：Interferon-gamma (IFNγ) is a pleiotropic cytokine implicated in tumor immune surveillance, with its antiproliferative, pro-apoptotic, and immune-provoking effects. Regarding the antitumor effects of IFNγ, IFNγ-dependent therapies have been proposed and have undergone many clinical trials for various cancer types but the outcomes were not satisfactory. Recent studies have suggested that cancer cells develop immune evasion strategies to escape from IFNγ-dependent immunosurveillance by various mechanisms. In this review, we summarize recent advances in the effects and molecular mechanisms of IFNγ on target cells, as well as potential immune escape mechanisms of tumor cells. Furthermore, we discuss how to target IFNγ signaling and overcome immune evasion to provide promising therapeutic strategies for the treatment of patients with cancer.

关 键 词：IFNΓ Immune evasion Immune therapy Tumor immunosurveillance 

分 类 号：R730.51[医药卫生—肿瘤]