血清25(OH)D、叶酸水平在孤独症谱系障碍患儿中的临床意义  

Clinical Significance of Serum 25(OH)D and Folic Acid Levels in Children with Autism Spectrum Disorder

作　　者：赵婷婷[1,2] 童光磊 李红[2] ZHAO Tingting;TONG Guanglei;LI Hong(The Fifth Clinical Medical College of Anhui Medical University,Hefei 230000,China)

机构地区：[1]安徽医科大学第五临床医学院,安徽合肥230000 [2]安徽医科大学附属省儿童医院(安徽省儿童医院)

出　　处：《中国医学创新》2023年第9期104-107,共4页Medical Innovation of China

基　　金：安徽医科大学校科研基金项目(2021xkj230)。

摘　　要：目的:了解孤独症谱系障碍(ASD)患儿血清25(OH)D、叶酸水平,分析其与患儿病情及发育情况的关系,以期为ASD患儿提供全新的药物治疗思路。方法:选取安徽省儿童医院2021年6月-2022年6月就诊的114例ASD患儿为ASD组,选取同期在本院体检的100例健康儿童为正常组,比较两组血清25(OH)D、叶酸水平,同时采用儿童孤独症评定量表(CARS)评估ASD患儿病情的严重程度、格里菲斯发育评估量表-中文版(GDS-C)评估ASD患儿的发育水平,并将血清指标与病情严重程度、发育水平进行相关性分析。结果:ASD组血清25(OH)D、叶酸水平分别为(33.28±11.05)、(14.74±4.84)ng/mL,均低于正常组的(44.71±6.32)、(23.17±6.16)ng/mL(P<0.05)。ASD组CARS评分为(33.11±2.01)分,GDS-C评分为(58.49±10.70)分。ASD组的血清25(OH)D、叶酸水平与CARS评分均呈负相关(P<0.05),与GDS-C评分均呈正相关(P<0.05)。结论:ASD患儿血清25(OH)D、叶酸水平较正常儿童降低,且与患儿的病情严重程度及发育水平相关。Objective:To investigate the levels of serum 25(OH)D and folic acid in children with autism spectrum disorder(ASD),and to analyze the relationship between serum 25(OH)D and folic acid in children with ASD,so as to provide a new idea of drug treatment for children with ASD.Method:A total of 114 children with ASD who received medical treatment in Anhui Provincial Children's Hospital from June 2021 to June 2022 were selected as the ASD group,and 100 healthy children who underwent physical examination in our hospital during the same period were selected as the normal group.The differences in serum 25(OH)D and folic acid levels between the two groups were compared.At the same time,the children's autism rating scale(CARS)was used to evaluate the severity of ASD,and Griffiths developmental scale-Chinese version(GDS-C)was used to evaluate the development level of ASD children,and the correlation between serum indicators and the severity of ASD and development level was analyzed.Result:Serum 25(OH)D and folic acid levels in ASD group were(33.28±11.05)ng/mL and(14.74±4.84)ng/mL,which were significantly lower than(44.71±6.32)ng/mL and(23.17±6.16)ng/mL in normal group(P<0.05).CARS score in ASD group was(33.11±2.01),GDS-C score was(58.49±10.70).Serum 25(OH)D and folic acid levels in ASD group were negatively correlated with CARS score(P<0.05),and positively correlated with GDS-C score(P<0.05).Conclusion:Serum levels of 25(OH)D and folic acid in children with ASD are lower than those in normal children,which are related to the severity and developmental level of the disease.

关 键 词：孤独症谱系障碍 25羟维生素D 叶酸 儿童孤独症评定量表 格里菲斯发育评估量表-中文版 

分 类 号：R749.94[医药卫生—神经病学与精神病学]