育龄期女性双相情感障碍躁狂发作患者性激素水平及其与攻击症状的相关性  

Sex Hormone Levels and Their Correlations with Aggressive Symptoms in Women of Childbearing Age with Manic Episodes of Bipolar Disorder

作　　者：阎琳 李猛 王淑贤 宋延艳 亓晶颖 张雪丽 邵玉单 李峥 翟永利 赵小会 李文峰 刘小俊 付慧鹏 孔德荣 YAN Lin;LI Meng;WANG Shuxian;SONG Yanyan;QI Jingying;ZHANG Xueli;SHAO Yudan;LI Zheng;ZHAI Yongli;ZHAO Xiaohui;LI Wenfeng;LIU Xiaojun;FU Huipeng;KONG Derong(Psychiatry Department,Zhengzhou Eight People’s Hospital/Zhengzhou Mental Heath Cental,Zhengzhou 450013,China)

机构地区：[1]郑州市第八人民医院/郑州市精神卫生中心精神科,河南郑州450013

出　　处：《河南医学研究》2023年第6期975-979,共5页Henan Medical Research

基　　金：河南省医学科技攻关计划项目(2018020866)。

摘　　要：目的探索育龄期女性双相情感障碍躁狂发作患者性激素水平及其与攻击症状的相关性。方法选取126例育龄期女性双相情感障碍躁狂发作患者为研究组(其中未服药组62例、服药组64例),以及125例育龄期健康女性为对照组,采用一般资料问卷采集研究组和对照组的一般资料,采用Young躁狂评定量表(YMRS)及外显攻击行为量表(MOAS)评定躁狂症状及攻击行为,测定两组血清性激素水平。结果3组方差分析显示,血清卵泡刺激素(FSH)、催乳素(PROL)、雌二醇(E 2)水平差异有统计学意义(F=5.171、31.634、4.040,P=0.024、<0.001、0.046);与对照组相比,未服药组、服药组血清PROL水平均升高(t=17.230、20.320,P<0.001),服药组血清FSH水平降低(t=1.347,P=0.003)、E 2水平升高(t=29.127,P=0.045);未服药组和服药组各血清性激素水平之间差异无统计学意义(P>0.05)。研究组血清孕酮(PROG)水平与自知力因子评分呈负相关(r=-0.179,P=0.045),血清睾酮(TESTO)水平与语言思维形式障碍因子评分、破坏攻击行为因子评分及YMRS总分呈正相关(r=0.213、0.228、0.213,P=0.017、0.010、0.017)。研究组PROG水平与自身攻击因子得分呈正相关(r=0.223,P=0.012),TESTO水平与财产攻击因子得分呈正相关(r=0.193,P=0.030)。结论育龄期女性双相情感障碍躁狂发作患者血清PROL水平升高,使用药物可能会引起FSH、E 2水平异常;血清PROG、TESTO水平与患者攻击性相关。Objective To explore the sex hormone levels and their correlations with aggressive symptoms in women of reproductive age with manic episodes of bipolar disorder.Methods A total of 126 female patients with bipolar disorder and manic episode at reproductive age were selected as the study group(62 cases in the the non-drug group and 64 cases in the the drug group),and 125 healthy women at reproductive age were selected as the control group.General data of the study group and control group were collected by general data questionnaire.Young mania rating scale(YMRS)and modified overt aggression scale(MOAS)were used to assess mania symptoms and aggressive behavior,and serum sex hormone levels were measured in the two groups.Results The difference analysis of the three groups showed that the serum levels of follicle stimulating hormone(FSH),prolactin(PROL),estradiol(E 2)were significantly different(F=5.171,31.634,4.040,P=0.024,<0.001,0.046).Compared with the control group,the serum PROL level of the non-drug group and the drug group were increased(t=17.230,20.320,P<0.001),the serum FSH level of the drug group was lower(t=1.347,P=0.003),and the serum E 2 level was increased(t=29.127,P=0.045).There were no significant differences in serum sex hormone levels between the non-drug group and the drug group(P>0.05).In the study group,the serum level of progesterone(PROG)was negatively correlated with the score of knowledge factor(r=-0.179,P=0.045),and the serum level of testosterone(TESTO)was positively correlated with the score of language and thought form disorder factor,the score of sabotage and aggression factor and the total score of YMRS(r=0.213,0.228,0.213,P=0.017,0.010,0.017).In the study group,PROG level was positively correlated with the score of self-aggression factor(r=0.223,P=0.012),and TESTO level was positively correlated with the score of property aggression factor(r=0.193,P=0.030).Conclusion The level of serum PROL in women of childbearing age with bipolar disorder manic episode is increased,and the use of drug

关 键 词：双相情感障碍 躁狂发作 性激素 育龄期 女性 

分 类 号：R749[医药卫生—神经病学与精神病学]