帕金森病脑脊液生物标志物的研究进展  

Research progress of cerebrospinal fluid biomarkers in Parkinson’s disease

作　　者：姜银银 张丽[1] JIANG Yin-yin;ZHANG Li(Department of Geriatrics,Brain Haspital Afiliated to Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学附属脑科医院老年医学科,210029

出　　处：《临床神经病学杂志》2023年第1期64-67,共4页Journal of Clinical Neurology

基　　金：国家自然科学基金面上项目(82171249)。

摘　　要：帕金森病是CNS一大常见的慢性退行性疾病,目前帕金森病的诊断主要依赖于临床特征,这阻碍了对帕金森病的早期识别和干预。研究表明CSF中存在与帕金森病病理密切相关的生物标记物。这些生物标志物都是极具潜力的早期诊断预测因子,可用于帕金森病和非典型帕金森综合征的鉴别诊断以及帕金森病相关临床症状的进展监测。本综述结合近几年的研究成果,对帕金森病CSF生物标志物的研究进展进行阐述和讨论。Parkinson’s disease is a common chronic degenerative disease of CNS.At present,the diagnosis of Parkinson’s disease relies mainly on clinical features,which hampers the early identification and intervention of Parkinson’s disease.Studies have shown that there are biomarkers closely related to the pathology of Parkinson’s disease in CSF.These biomarkers are potential predictors for early diagnosis,which can be used for the differential diagnosis of Parkinson’s disease versus atypical parkinsonian syndromes and the progressive monitoring of clinical symptoms related to Parkinson’s disease.Combined with the research results in recent years,this review expounds and discusses the research progress of CSF biomarkers in Parkinson’s disease.

关 键 词：帕金森病 早期诊断 CSF 生物标志物 

分 类 号：R742.5[医药卫生—神经病学与精神病学]