2014—2019年珠海市新生儿唇腭裂分布规律分析  

Analysis of dynamic distribution of cleft lip and palate in Zhuhai city from 2014 to 2019

作　　者：张红忠[1] 戚小兵[1] 张卫 冯雅楠[3] ZHANG Hongzhong;QI Xiaobing;ZHANG Wei;FENG Ya'nan(Zhuhai Maternity&Child Health-care Hospital,Zhuhai,Guangdong 519000,China;BGI Genomics,BGI-Shenzhen,Shenzhen,Guangdong 518083,China;Shihezi University,Shihezi,Xinjiang 832061,China)

机构地区：[1]珠海市妇幼保健院,广东珠海519000 [2]深圳华大基因股份有限公司,广东深圳518083 [3]石河子大学,新疆石河子832061

出　　处：《中国优生与遗传杂志》2023年第3期614-618,共5页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨珠海市围生儿唇腭裂分布规律,为唇腭裂的早期预防与干预提供数据支撑。方法基于珠海市以医院为基础的出生缺陷监测系统,获取2014—2019年唇腭裂围生儿信息。结果监测的198003例围生儿中,发生唇腭裂361例,其中单纯唇裂55例,单纯腭裂77例,唇裂合并腭裂229例,总唇腭裂发生率为18.23/万。唇腭裂发生率男性高于女性,城镇高于乡村,2014年不同类型唇腭裂发生率均最低,随着年份变化,不同类型唇腭裂分布,差异具有统计学意义(P<0.001)。结论与前期相比,2014—2019年珠海市围生儿唇腭裂发生率有所降低,应加强社会孕前、孕期保健意识,增加优生遗传咨询,提高产前超声检查覆盖率及准确性,有效减少围生儿唇腭裂的发生。Objective To get the distribution profile of cleft lip and palate in perinatal infants as well as the theoretical basis for the prevention and intervention of cleft lip and palate.Methods The datasets of infants with cleft lip and palate in Zhuhai city during 2014 to 2019 were extracted from the hospital-based birth defect monitoring system.Results 361 cases with a cleft defects among 198003 perinatal infants were recorded,including 55 cleft lip only cases,77 cleft palate only cases,and 229 cleft palate with cleft lip cases.The overall prevalence was 18.23 per 10000 births.The cleft lip and palate incidence was higher in males than in females,and it was higher in urban regions.The incidence of different types of cleft lip and palate in 2014 was the lowest.With the change of years,the distributions of different types of cleft lip and palatewere diverse significantly(P<0.001).Conclusion The incidence of cleft lip and palate in perinatal infants in Zhuhai city decreased from 2014to 2019 than previous.We should strengthen the awareness of health care before and during pregnancy should be strengthened,sufficient genetic counseling should be provided,and the coverage and accuracy of prenatal ultrasound examination should be improved,to effectively reduce the incidence of cleft lip and palate in perinatal infants.

关 键 词：珠海市 唇腭裂 围生儿 动态分布 

分 类 号：R782.2[医药卫生—口腔医学]