脑血管病轻度认知障碍与血浆不对称二甲基精氨酸、同型半胱氨酸的相关性及预测价值研究  

Study on Correlation and Predictive Value between Mild Cognitive Disorder of Cerebral Vascular Disease and Plasma Asymmetric Dimethylarginine and Homocysteine

作　　者：阮红清 阮红花 RUAN Hongqing;RUAN Honghua(Xinyu Mining Hospital,Xinyu 338000,China)

机构地区：[1]新余矿业医院,江西新余338000 [2]新余袁河医院

出　　处：《中国医学创新》2023年第8期130-133,共4页Medical Innovation of China

摘　　要：目的:研究脑血管病轻度认知障碍与血浆不对称二甲基精氨酸(ADMA)、同型半胱氨酸(Hcy)的相关性。方法:本研究采用前瞻性研究方法,以新余矿业医院2017年1月-2021年1月诊断的脑血管病患者120例作为研究对象,其中认知障碍患者48例,均为轻度认知障碍患者,纳为观察组,认知正常患者72例,纳为对照组。采用酶联免疫法对患者的ADMA及Hcy水平进行检测,比较两组患者ADMA及Hcy水平之间的差异,分析脑血管病患者轻度认知障碍与血浆ADMA、Hcy的相关性。结果:观察组MoCA评分低于对照组、ADMA及Hcy水平均显著高于对照组(P<0.05);通过相关性分析,MoCA与ADMA、Hcy水平均呈负相关,ADMA、Hcy联合检测的敏感度、准确度均显著高于单独检测(P<0.05);通过ROC曲线分析,联合检测的曲线下面积显著高于单独检测(P<0.05),观察组ADMA、Hcy水平的临界值分别为0.68μmol/L、30.26μmol/L。结论:脑血管病轻度认知障碍与ADMA、Hcy呈现显著的相关性,可作为日后认知障碍的重要诊断参考。Objective:To investigate the correlation between mild cognitive disorder of cerebral vascular disease and plasma asymmetric dimethylarginine(ADMA)and homocysteine(Hcy).Method:A prospective study was used in this study.A total of 120 patients diagnosed with cerebral vascular disease in Xinyu Mining Hospital from January 2017 to January 2021 were included in the study.Among them,48 patients with cognitive disorder,all of them mild cognitive disorder,were included in the observation group,and 72 patients with normal cognition were included in the control group.The levels of ADMA and Hcy in patients were detected by enzyme-linked immunosorbent assay,and the differences between the two groups were compared,and the correlation between mild cognitive disorder and plasma ADMA and Hcy in patients with cerebral vascular disease was analyzed.Result:The MoCA score of the observation group was lower than that of the control group,and the levels of ADMA and Hcy were significantly higher than those of the control group(P<0.05).Through correlation analysis,there were negatively correlation between MoCA and ADMA,Hcy levels,and the sensitivity and accuracy of combined detection of ADMA and Hcy were significantly higher than those of single detection(P<0.05).Through ROC curve analysis,the area under the curve of joint detection was significantly higher than that of single detection(P<0.05),and the critical values of ADMA and Hcy levels in the observation group respectively was 0.68μmol/L,30.26μmol/L.Conclusion:Mild cognitive disorder of cerebral vascular disease is significantly correlated with ADMA and Hcy,which can be used as an important diagnostic reference for cognitive impairment in the future.

关 键 词：脑血管病 认知障碍 不对称二甲基精氨酸 同型半胱氨酸 

分 类 号：R749.13[医药卫生—神经病学与精神病学]