Adjuvant therapy for orbital non-rhabdomyosarcoma soft tissue sarcoma:comparison of long-term outcome between radiotherapy and chemotherapy  

作　　者：Xiao-Feng Li Rui-Qi Ma Xue Wu Lu Gan Zhi-Yu Peng Jiang Qian 

机构地区：[1]Department of Ophthalmology,Eye and ENT Hospital of Fudan University,Shanghai 200031,China [2]Laboratory of Myopia,Chinese Academy of Medical Sciences,Shanghai 200031,China [3]NHC Key Laboratory of Myopia,Fudan University,Shanghai 200031,China [4]Department of Ophthalmology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2023年第3期402-410,共9页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China (No.82171099,No.82000940,No.81970835,No.81800867);the Natural Science Foundation of Shanghai (No.20ZR1409500)。

摘　　要：AIM:To illustrate clinicopathological features of orbital non-rhabdomyosarcoma soft tissue sarcoma(NRSTS),and to compare the treatment outcome between postoperative radiotherapy(RT) and chemotherapy in a retrospective analysis nearly 20y.METHODS:A retrospective cohort study of 56 patients with orbital NRSTS were reviewed,34 of whom received postoperative RT,and 22 received postoperative chemotherapy.The clinicopathological features,local recurrence,metastases,and survival data were recorded.Survival analysis was performed using the Kaplan-Meier method.RESULTS:During follow-up(111.8mo,ranged 8-233mo) for 56 patients,19 patients of them developed local recurrence,and 7 patients developed distant metastases.Fifteen patients died during follow-up period.Overall survival rates considering the whole study group was 78.57% at 5y,and 72.16% at 10y after the initial diagnosis.Compared with chemotherapy,RT was associated with lower risk of local recurrence [hazard ratio for RT vs chemotherapy,0.263,95% confidence interval(CI),0.095-0.728,P=0.0015];with lower risk of distant metastasis(hazard ratio for RT vs chemotherapy,0.073,95%CI,0.015-0.364,P=0.0014);and with lower risk of death from disease(hazard ratio for RT vs chemotherapy,0.066,95%CI,0.022-0.200,P<0.0001).The 5-year survival rate in RT group was 97.06% compared to 50% in chemotherapy group.CONCLUSION:In patients with orbital NRSTS,postoperative RT provides better control of local recurrence,distant metastasis,and death from disease than chemotherapy.RT is the more preferrable adjuvant therapy compared to chemotherapy possibly.

关 键 词：orbital tumor non-rhabdomyosarcoma soft tissue sarcoma oncological outcome adjuvant radiotherapy adjuvant chemotherapy 

分 类 号：R739.7[医药卫生—肿瘤]