阿替普酶联合尤瑞克林及丁苯酞治疗急性脑梗死的效果观察  

Clinical effect of Alteplase combined with Urinary Kallidinogenase and Butylphthalide injection on acute cerebral infarction after intrav enous thrombolysis

作　　者：赵湧频 上官亚菲[1] 李裕峰 熊涛[1] ZHAO Yongbin;SHANGGUAN Yafei;LI Yufeng;XIONG Tao(Department of Neurology,Guiyang First People’s Hospital,Guiyang,Guizhou 550000,China)

机构地区：[1]贵阳市第一人民医院神经内科,贵州贵阳550000

出　　处：《医药前沿》2023年第4期29-32,共4页Journal of Frontiers of Medicine

摘　　要：目的:观察阿替普酶静脉溶栓治疗后与尤瑞克林及丁苯欧注射液联合使用治疗急性脑梗死的临床效果及安全性。方法:选取贵阳市第一人民医院神经内科2020年12月—2022年12月收治的54例急性脑梗死患者,按照随机数字表法分为对照组与观察组各27例。对照组予以阿替普酶及尤瑞克林治疗,观察组予以阿替普酶联合尤瑞克林及丁苯酞注射液治疗,比较两组患者的神经功能缺损(NIHSS)评分,日常生活能力(ADL)评分、临床疗效及不良反应。结果:治疗后,两组的NIHSS评分均低于本组治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组ADL评分、BI指数均升高,且观察组高于对照组,差异有统计学意义(P<0.05);两组的临床疗效比较,观察组的总有效率(88.9%)高于对照组(63.0%),差异有统计学意义(P<0.05);观察组的不良反应发生率(7.4%)与对照组(14.8%)比较,差异无统计学意义(P>0.05)。结论:阿替普酶联合尤瑞克林及丁苯酞注射液静脉使用可显著改善急性脑梗死患者的神经功能症状和日常生活能力及生活质量,临床效果显著,且不会增加不良反应发生率。Objective To investigate the clinical efcacy and safety of the combination of Alteplase and urinary kallidinogenase and Butylphthalide injection in the treatment of acute cerebral infarction after intravenous thrombolysis.Methods Fifty-four patients with acute cerebral infarction admitted to the Department of Neurology of the First People’s Hospital of Guiyang from December 2020 to December 2022 were randomly divided into control group and observation group by random number table method,with 27 patients in each group.Control group was treated with Alteplase and urinary kallidinogenase,observation group was treated with Alteplase combined with Urinary Kallidinogenase and Butylphthalein injection.The neurological function defect(NIHSS score),daily living ability(ADL score)clinical efcacy and adverse reactions(nausea,vomiting,flushing,fever,abdominal discomfort,etc.).Results The NIHSS score of the two groups after treatment was lower than that of the group before treatment,and that of observation group was lower than that of control group(P<0.05);The ADL score of the two groups after treatment was higher than that of the group before treatment,and that of observation group was higher than that of control group(P<0.05);The total effective rate of observation group(88.9%)was higher than that of control group(63.0%),(P<0.05);During the treatment of acute cerebral infarction,the incidence of adverse reactions in observation group(7.4%)was not signifcantly different from that in control group(14.8%)(P>0.05).Conclusion Alteplase combined with urinary kallidinogenase and Butylphthalide injection can significantly improve the neurological symptoms,daily living ability and quality of life of patients with acute cerebral infarction,and the clinical efcacy and safety are higher.

关 键 词：急性脑梗死 阿替普酶 尤瑞克林 丁苯酞注射液 神经功能 生活能力 

分 类 号：R742[医药卫生—神经病学与精神病学]