丙泊酚联合不同剂量舒芬太尼在老年结肠镜检查中的效果对比分析  

Effect of Propofol combined with different doses of Sufentanil on elderly patients undergoing colonoscopy

作　　者：张青枝 李静 董然然 ZHANG Qingzhi;LI Jing;DONG Ranran(Department of Anesthesia,Liaocheng Infectious Diseases Hospital,Liaocheng,Shandong 252000,China)

机构地区：[1]聊城市传染病医院麻醉科,山东聊城252000

出　　处：《医药前沿》2023年第4期37-40,共4页Journal of Frontiers of Medicine

摘　　要：目的:对比分析丙泊酚联合不同剂量舒芬太尼在老年结肠镜检查中效果。方法:选取2021年4月—2022年4月期间聊城市传染病医院麻醉科收治的无痛结肠镜检查术的老年患者117例。采用随机数字表法分成极小剂量组、小剂量组和较小剂量组各39例,分别静脉注射0.05μg/kg、0.1μg/kg和0.15μg/kg舒芬太尼联合靶控输注丙泊酚,比较各组的生理指标、EC_(50)、丙泊酚总消耗量、意识恢复时间以及不良反应。结果:三组患者在结肠镜检查过程中,T_(1)~T_(4)时刻的MAP和HR较T_(0)时刻均有下降,差异有统计学意义(P<0.05);极小剂量组、小剂量组、较小剂量组结肠镜检查期间丙泊酚的EC_(50)分别为2.81μg/mL、2.07μg/mL、1.91μg/mL,随着舒芬太尼剂量的增大,丙泊酚EC_(50)呈现递减趋势,各组比较,差异有统计学意义(P<0.05);较小剂量组的丙泊酚总消耗量明显的少于极小剂量组和小剂量组,意识恢复时间短于极小剂量组和小剂量组,差异有统计学意义(P<0.05).结论:丙泊酚联合较少剂量舒芬太尼应用于老年结肠镜检查,麻醉效果好,降低了丙泊酚的EC_(50),减少了丙泊酚的总消耗量,加快了术后意识恢复,其中采用0.15μg/kg舒芬太尼联合丙泊酚的患者意识恢复时间更快。Objective To investigate the effect of Propofol combined with different doses of Sufentanil on EC_(50)in elderly patients undergoing colonoscopy.Methods 117 elderly patients undergoing painless colonoscopy admitted to the Department of Anesthesia of Liaocheng Infectious Diseases Hospital from April 2021 to April 2022 were selected as the study subjects.Randomized number table method was used to divide 39 patients into minimal dose group,smaller dose group and small dose group,with intravenous injection of 0.05μg/kg,0.1μg/kg and 0.15μg/kg sufentanil combined with target-controlled infusion of propofol was used to compare the physiological indexes,EC_(50),total consumption of propofol,recovery time of consciousness and adverse reactions in each group.Results MAP and HR at T_(1)-T_(4)were lower than those at T_(0)during colonoscopy in the three groups(P<0.05);The EC_(50)of propofol during colonoscopy in the minimal dose group,the small dose group and the small dose group was respectively 2.81μg/mL,2.07μg/mL and 1.91μg/mL,with the increase of sufentanil dose,the EC_(50)of propofol showed a decreasing trend,and the difference was statistically signifcant(P<0.05);The total consumption of propofol in the small dose group was signifcantly less than that in the minimal dose group and in the smaller dose group,and the recovery time of consciousness was shorter than that in the minimal dose group and in the smaller dose group,with a statistically signifcant difference.

关 键 词：丙泊酚 舒芬太尼 结肠镜检查 麻醉 半数有效血浆浓度 

分 类 号：R574[医药卫生—消化系统]