Hydroarylation of terminal alkynes with arylboronic acids catalyzed by low loadings of palladium  

作　　者：Lei Xu Shiyu Li Qi Zhang Ning Deng Biao Zhang Huajian Xu 

机构地区：[1]School of Chemistry and Chemical Engineering,School of Food and Biological Engineering,Institute of Industry&Equipment Technology,Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering,Hefei University of Technology,Hefei 230009,China

出　　处：《Chinese Chemical Letters》2023年第2期165-169,共5页中国化学快报（英文版）

基　　金：financial support from the National Natural Science Foundation of China (No. 21472033);the National Key R&D Program of China (No. 2018YFB1501604);the Fundamental Research Funds for the Central Universities (No. PA2020GDKC0021)。

摘　　要：The hydroarylation reaction of terminal alkynes with arylboronic acids catalyzed by low(400 ppm) loadings of palladium has been developed. The reaction is broad in scope and high-yielding, even on multigram scale. It is suitable for the synthesis of alkenes labeled with deuterium, and for the late-stage modification of bioactive molecules.

关 键 词：HYDROARYLATION Low loadings Terminal alkyne Deuterium-labeled PALLADIUM 

分 类 号：O621.251[理学—有机化学]