Copper-catalyzed chemoselective heterocyclization of two isocyanides:Facile access to pyrroloazepinone derivatives  

作　　者：Xiaoyu Guo Jinhuan Dong Yunjie Zhu Lan Bao Zhongyan Hu Xianxiu Xu 

机构地区：[1]College of Chemistry,Chemical Engineering and Materials Science,Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong,Key Laboratory of Molecular and Nano Probes,Ministry of Education,Institute of Molecular and Nano Science,Shandong Normal University,Ji'nan 250014,China

出　　处：《Chinese Chemical Letters》2023年第2期202-205,共4页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China (Nos. 22001151, 22171168, 22101159);Taishan Scholar Program of Shandong Province and Shandong Provincial Natural Science Foundation (Nos. ZR2019QB004, ZR2020QB019) is gratefully acknowledged。

摘　　要：A Cu-catalyzed chemoselective heterocyclization of o-cinnamoyl arylisocyanides with α-substituted tosylmethyl isocyanides is developed for the efficient synthesis benzopyrroloazepinones. An isocyanide insertion into the C–Cu bond of organocuprate intermediate is involved for the formation of the sevenmembered azepinone ring.

关 键 词：ISOCYANIDES Domino reactions Pyrroloazepinones 

分 类 号：O626[理学—有机化学]