Hawanoids A–E, unprecedented diterpenoids with PAF-induced platelet aggregation inhibitory activities from the deep-sea-derived fungus Paraconiothyrium hawaiiense  

作　　者：Shushuai Chen Hongxin Liu Saini Li Yuchan Chen Wei Ye Haohua Li Haibo Tan Dongli Li Zhaoming Liu Weimin Zhang 

机构地区：[1]State Key Laboratory of Applied Microbiology Southern China,Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Institute of Microbiology,Guangdong Academy of Sciences,Guangzhou 510070,China [2]School of Biotechnology and Health Sciences,Wuyi University,Jiangmen 529020,China [3]Program for Natural Product Chemical Biology,Key Laboratory Plant Resources Conservation and Sustainable Utilization,South China Botanical Garden,Chinese Academy of Sciences,Guangzhou 510650,China

出　　处：《Chinese Chemical Letters》2023年第2期416-419,共4页中国化学快报（英文版）

基　　金：funded by National Natural Science Foundation of China (Nos. 41906106, 31272087);the Natural Science Foundation of Guangdong Province, China (No. 2021A1515011416);Guangdong Special Support Program (No. 2019TQ05Y375);Guangdong Provincial Special Fund for Marine Economic Development Project (No. GDNRC [2021]054)。

摘　　要：Hawanoids A–E(1–5), five highly cyclized diterpenoids were isolated from the deep-sea-derived fungus Paraconiothyrium hawaiiense FS482. Compounds 1 and 2 possessed an unprecedented tetracyclo[6.6.2.0^(2,7).0^(11,15)]cetane carbon skeleton while 3 and 4 possessed an unusual 11,14-macrocyclic ether moiety in phomactin family. Their structures including the stereo-chemistry were determined through spectroscopic analysis, X-ray diffractions and computational calculations. The plausible biosynthetic pathway was proposed based on the predicted biosynthetic gene cluster. All of the isolated compounds exhibited inhibitory activities against PAF-induced platelet aggregation. The molecular docking study was carried out understand the interaction between the PAF receptor and hawanoids with different skeletons.

关 键 词：DITERPENOIDS Deep-sea-derived fungus Biosynthetic pathway Platelet aggregation inhibition Molecular docking 

分 类 号：R284[医药卫生—中药学] O629.61[医药卫生—中医学]