Biological regulation on synovial fibroblast and the treatment of rheumatoid arthritis by nobiletin-loaded tetrahedral framework nucleic acids cargo tank  

作　　者：Yuting Wen Mei Zhang Yangxue Yao Yang Gao Xiaolin Zhang Yunfeng Lin Xiaoxiao Cai 

机构地区：[1]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2023年第2期446-451,共6页中国化学快报（英文版）

基　　金：supported by the National Key R&D Program of China (No. 2019YFA0110600);National Natural Science Foundation of China (Nos. 82171006, 81970986);Sichuan Province Youth Science and Technology Innovation Team (No. 2022JDTD0021)。

摘　　要：The hyperplasia and destruction of synovial tissue have an important impact on the development of rheumatoid arthritis(RA), the abnormal proliferation and migration of synovial fibroblast in synovial tissue is similar to tumor cells. Targeting anomalous synovial fibroblast and designing a high bioavailability nano drug delivery system can reduce the dosage for the treatment of rheumatoid arthritis and it is of great significance to reduce toxic and side effects and improve curative effect. In this experiment, the nobiletin-loaded tetrahedral framework nucleic acids cargo tank was established, carrying antiinflammatory small molecule monomer drug nobiletin with minimal bioavailability. Both in vitro cell experiments and in vivo animal studies proved the nano cargo tank enhance the role of nobiletin in reducing the invasiveness of pathological synovial fibroblast and promote their apoptosis, effectively alleviate the disease development of rheumatoid arthritis.

关 键 词：Tetrahedral framework nucleic acids NOBILETIN Rheumatoid arthritis Synovial fibroblast APOPTOSIS 

分 类 号：R593.22[医药卫生—内科学]