云南高校图书馆联盟文献共享服务平台- NOBILETIN

NOBILETIN: 作品数：11被引量：18H指数：2; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张兰白雪陈林玉张健张祥建更多>>; 相关机构：广东药科大学河北医科大学第二医院中国药科大学更多>>; 相关期刊：《Acta Pharmacologica Sinica》《Pharmacology & Pharmacy》《Journal of Chinese Pharmaceutical Sciences》《Food Science and Human Wellness》更多>>; 相关基金：国家自然科学基金广东省科技计划工业攻关项目更多>>

Natural sources,refined extraction,biosynthesis,metabolism,and bioactivities of dietary polymethoxyflavones(PMFs)被引量：2: 《Food Science and Human Wellness》2024年第1期27-49,共23页Renyou Gan Yi Liu Hang Li Yu Xia Huan Guo Fang Geng Qiguo Zhuang Huabin Li Dingtao Wu; supported by the Local Financial Funds of National Agricultural Science and Technology Center,Chengdu,China(NASC2021KR01);the Agricultural Science and Technology Innovation Program(ASTIP-IUA-2022002)。; Polymethoxyflavones(PMFs)are a type of uncommon dietary flavonoids,characterized by more than one methoxy group,which exist in limited plant species,like Citrus species and Kaempferia parviflora.In addition,different ...; 关键词：NOBILETIN O-METHYLTRANSFERASES Gut microbiota BIOACTIVITIES Molecular mechanism

Biological regulation on synovial fibroblast and the treatment of rheumatoid arthritis by nobiletin-loaded tetrahedral framework nucleic acids cargo tank被引量：1: 《Chinese Chemical Letters》2023年第2期446-451,共6页Yuting Wen Mei Zhang Yangxue Yao Yang Gao Xiaolin Zhang Yunfeng Lin Xiaoxiao Cai; supported by the National Key R&D Program of China (No. 2019YFA0110600);National Natural Science Foundation of China (Nos. 82171006, 81970986);Sichuan Province Youth Science and Technology Innovation Team (No. 2022JDTD0021)。; The hyperplasia and destruction of synovial tissue have an important impact on the development of rheumatoid arthritis(RA), the abnormal proliferation and migration of synovial fibroblast in synovial tissue is similar...; 关键词：Tetrahedral framework nucleic acids NOBILETIN Rheumatoid arthritis Synovial fibroblast APOPTOSIS

Deciphering the latent mechanism of nobiletin in the treatment of metabolic syndrome based on network pharmacology and molecular docking: 《Journal of Chinese Pharmaceutical Sciences》2022年第11期803-823,共21页Xiaohui Du Hongyan Yang Tao Wang Hongxia Cui Yu Lin Hongling Li; Basic Scientific Research Operating Expenses of Heilongjiang Provincial Universities (Grant No. 2018-KYYWF-0100)。; Nobiletin(NOB) may have a potential effect on metabolic syndrome. In the present study, we aimed to explore the latent mechanisms of NOB for the treatment of metabolic syndrome based on network pharmacology and molecu...; 关键词：NOBILETIN Metabolic Syndrome Network pharmacology Molecular docking

Novel treatment for refractory rheumatoid arthritis with total glucosides of paeony and nobiletin codelivered in a self-nanoemulsifying drug delivery system被引量：2: 《Acta Pharmacologica Sinica》2022年第8期2094-2108,共15页Biao Qu Xiao-lin Wang De-chong Zheng Chu-tian Mai Zhong-qiu Liu Hua Zhou Ying Xie; supported by the Science and Technology Development Fund,Macao SAR,China(File no.0067/2019/A2 and 0075/2019/AMJ).; Patients with refractory rheumatoid arthritis(RA)remain a substantial clinical problem,while the overexpression of P-glycoprotein(P-gp)on their lymphocytes may contribute to resistance to anti-rheumatic drugs.This stu...; 关键词：refractory rheumatoid arthritis P-GLYCOPROTEIN total glucosides of paeony NOBILETIN self-nanoemulsifying drug delivery systems

Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma被引量：4: 《Cancer Biology & Medicine》2021年第1期227-244,共18页Tingting Chen Liu Liu Yonghong Zou Xiaoyan Hu Wenfeng Zhang Tao Zhou Xi Luo Weihua Fu Jie Xu; supported by the National Natural Science Foundation of China(Grant Nos.81772702 and 81502214)。; Objective:Natural extracts,including nobiletin,have been reported to enhance the efficacy and sensitivity of chemotherapeutic drugs.However,whether and how nobiletin affects tumor growth and progression in renal cell ...; 关键词：NOBILETIN SKP2 palbociclib SYNERGISTIC renal cell carcinoma

Nobiletin and tangeretin(citrus polymethoxyflavones): an overview on their chemistry, pharmacology and cytotoxic activities against breast cancer: 《Journal of Chinese Pharmaceutical Sciences》2020年第7期443-454,共12页Eric Wei Chiang Chan Oi Yoon Michelle Soo Yong Hui Tan Siu Kuin Wong Hung Tuck Chan; The fruit peel of Citrus species(Chenpi),particularly those of mandarin oranges,is a useful source of food and medicine in China.Flavonoids from the citrus fruit peel are mainly polymethoxyflavones(PMFs),of which nobi...; 关键词：Polymethoxylated flavones NOBILETIN Tangeretin Breast cancer cells Structure-activity relationship

Nobiletin对慢性低灌注损伤后小鼠脑海马神经血管单元的影响被引量：2: 《中国老年学杂志》2020年第8期1732-1735,共4页赵宇红陈世坚李坤平郑凌云; 广东省科技计划资助项目(2017A030303080)。; 目的观察川陈皮素(NOB)对小鼠慢性脑低灌注(CCH)模型海马区神经血管单元各主要组分的保护作用。方法昆明小鼠随机分为对照组、模型组和NOB高、低剂量处理组各10只,模型组和NOB处理组进行双侧颈总动脉结扎,对照组不结扎。术后2 w进行旷...; 关键词：慢性脑低灌注川陈皮素神经血管单元海马学习记忆

Nobiletin and its derivatives overcome multidrug resistance(MDR) in cancer:total synthesis and discovery of potent MDR reversal agents被引量：4: 《Acta Pharmaceutica Sinica B》2020年第2期327-343,共17页Senling Feng Huifang Zhou Deyan Wu Dechong Zheng Biao Qu Ruiming Liu Chen Zhang Zhe Li Ying Xie Hai-Bin Luo; supported by National Key R&D Program of China(2017YFB0202600);Macao Science and Technology Development Fund,Macao Special Administrative Region(003/2017/A1to Ying Xie,China);National Natural Science Foundation of China(21572279,21877134,81602955 and 81703341);Guangdong Province Higher Vocational Colleges&Schools Pearl River Scholar Funded Scheme(2016,China).; Our recent studies demonstrated that the natural product nobiletin(NOB)served as a promising multidrug resistance(MDR)reversal agent and improved the effectiveness of cancer chemotherapy in vitro.However,low aqueous s...; 关键词：NOBILETIN CANCER MULTIDRUG resistance Mechanism P-gp inhibition Reversal agents Solubility Total synthesis

Nobiletin protects against metabolic syndrome by enhancing circadian rhythms: 《中国药理学与毒理学杂志》2019年第9期686-687,共2页HE Bao-kun; OBJECTIVE Dysregulation of circadian rhythms is associated with metabolic dysfunction,yet it is unclear whether enhancing clock function by small molecules can ameliorate metabolic disorders.METHODS We used an unbiase...; 关键词：NOBILETIN circadian rhythms metabolic syndrome RORα/γreceptors

Nobiletin Prevents Body Weight Gain and Bone Loss in Ovariectomized C57BL/6J Mice被引量：2: 《Pharmacology & Pharmacy》2014年第10期959-965,共7页Young-Sil Lee Midori Asai Sun-Sil Choi Takayuki Yonezawa Toshiaki Teruya Kazuo Nagai Je-Tae Woo Byung-Yoon Cha; Obesity and osteoporosis are associated with estrogen deficiency following menopause. Therefore, it is important to prevent and treat both disorders to maintain a healthy life in postmenopausal women. Nobiletin, a pol...; 关键词：NOBILETIN OVARIECTOMY OBESITY LIPID and GLUCOSE Metabolism Bone Mineral Density

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