OVARIECTOMY

作品数：68被引量：203H指数：8
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相关领域：医药卫生更多>>
相关作者：李青南梁念慈刘晓青吴铁崔燎更多>>
相关机构：南通大学广东医学院上海中医药大学烟台市烟台山医院更多>>
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相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划更多>>
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Low-molecular-weight estrogenic phytoprotein suppresses osteoporosis development through positive modulation of skeletal estrogen receptors
《Bioactive Materials》2024年第12期299-315,共17页John Akrofi Kubi Augustine Suurinobah Brah Kenneth Man Chee Cheung Andy Chun Hang Chen Yin Lau Lee Kai-Fai Lee Wei Qiao Yibin Feng Kelvin Wai Kwok Yeung 
supported by the Seed Fund for Translational and Applied Research from the University Research Committee(URC),The University of Hong Kong(HKU),Hong Kong China(Project Codes:201910160024 and 202010160009).
Age-related osteoporosis is a metabolic skeletal disorder caused by estrogen deficiency in postmenopausal women.Prolonged use of anti-osteoporotic drugs such as bisphosphonates and FDA-approved anti-resorptive selecti...
关键词：Ovariectomy(ovx) OSTEOPOROSIS Osteoblast functions Estrogen receptors(ERs) HKUOT-S2 protein 
DEC1 deficiency protects against bone loss induced by ovariectomy by inhibiting inflammation被引量：1
《Journal of Biomedical Research》2024年第6期613-627,共15页Lan Lin Zhiyi Qiang Kaiao Chen Ying Huo Wei Liu Jian Yang 
supported by the National Natural Science Foundation of China(Grant Nos.82073934 and 81872937 to J.Y.);the Special Foundation for Clinical Science and Technology of Jiangsu Province(Grant No.JX10114120).
Studies have shown that differentiated embryo-chondrocyte expressed gene 1(DEC1)promotes osteoblast osteogenesis.To investigate the role of DEC1 in postmenopausal osteoporosis,we used the two genotypes of mice(Dec1+/+...
关键词：DEC1 postmenopausal osteoporosis ESTROGEN OSTEOBLASTS OSTEOCLASTS 
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
《Bone Research》2024年第3期734-744,共11页Zhenqiang Yao Akram Ayoub Venkatesan Srinivasan Jun Wu Churou Tang Rong Duan Aleksa Milosavljevic Lianping Xing Frank H.Ebetino Alison J.Frontier Brendan F.Boyce 
funded by National Institutes of Health,National Institute on Aging,grant numbers,R01AG076731,R01AG049994;National Institute for Arthritis and Musculoskeletal and Skin Diseases,R01AR043510,and P30 AR069655。
Osteoporosis remains incurable.The most widely used antiresorptive agents,bisphosphonates(BPs),also inhibit bone formation,while the anabolic agent,teriparatide,does not inhibit bone resorption,and thus they have limi...
关键词：res CONJUGATE phosphonate 
Cinobufotalin prevents bone loss induced by ovariectomy in mice through the BMPs/SMAD and Wnt/β-catenin signaling pathways
《Animal Models and Experimental Medicine》2024年第3期208-221,共14页Da-zhuang Lu Li-jun Zeng Yang Li Ran-li Gu Meng-long Hu Ping Zhang Peng Yu Xiao Zhang Zheng-wei Xie Hao Liu Yong-sheng Zhou 
Beijing Natural Science Foundation,Grant/Award Number:L222145 and L222030;Emerging Engineering Interdisciplinary Project and the Fundamental Research Funds for the Central Universities,Grant/Award Number:PKU2022XGK008;Peking University Medicine Fund of Fostering Young Scholars’Scientific&Technological Innovation,Grant/Award Number:BMU2022PY010。
Background:Osteoporosis is a chronic bone disease characterized by bone loss and decreased bone strength.However,current anti-resorptive drugs carry a risk of various complications.The deep learning-based efficacy pre...
关键词：BMPs/SMAD bone loss cinobufotalin hBMMSCs OSTEOGENESIS OSTEOPOROSIS Wnt/β-catenin signaling pathways 
Sinomenine increases osteogenesis in mice with ovariectomyinduced bone loss by modulating autophagy
《World Journal of Stem Cells》2024年第5期486-498,共13页Hai-Xiang Xiao Lei Yu Yu Xia Kai Chen Wen-Ming Li Gao-Ran Ge Wei Zhang Qing Zhang Hong-Tao Zhang De-Chun Geng 
Supported by National Natural Science Foundation of China,No.82072425.
BACKGROUND A decreased autophagic capacity of bone marrow mesenchymal stromal cells(BMSCs)has been suggested to be an important cause of decreased osteogenic differentiation.A pharmacological increase in autophagy of ...
关键词：SINOMENINE OSTEOGENESIS AUTOPHAGY OVARIECTOMY OSTEOPOROSIS 
Lactobacillus plantarum CCFM1180 attenuates obesity induced by estrogen deficiency by activating estrogen receptor alpha in abdominal adipose tissue and regulating gut microbiota-derived metabolites
《Food Science and Human Wellness》2024年第2期765-777,共13页Qian Chen Chunxia Mei Min Guo Botao Wang Haiqin Chen Jianxin Zhao Gang Wang Wei Chen 
funded by the National Natural Science Foundation of China(31972052,32021005,31820103010);the Fundamental Research Funds for the Central Universities(JUSRP22006,JUSRP51501);the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province。
Lipid metabolism disorders commonly occur during menopause.Estrogen deficiency has been shown to lead to excessive energy intake and abnormal lipid metabolism in ovariectomized rats,resulting in obesity.Probiotics exh...
关键词：Bile acid Gut microbiota MENOPAUSE OVARIECTOMY Short chain fatty acid 
Effect of Menopausal Hormone Replacement Therapy on Cytokine Patterns in a Perimenopausal Mouse Model Established by the Ovarian Castration Method
《Chinese Journal of Biomedical Engineering(English Edition)》2024年第1期40-48,共9页HE Bin-bin ZHANG Ju-shun WANG Jin-yong 
Objective: To investigate the effect of perimenopausal hormone replacement therapy(HRT) on cytokine patterns in a perimenopausal mouse model established by ovarian castration. Methods: The mice were divided into natur...
关键词：MENOPAUSE hormone replacement therapy(HRT) OVARIECTOMY mouse model cytokine pattern 
Carya cathayensis Leaf Extract Exerts Estrogenic Effects on Hepatic Lipogenesis and Adipocytes Differentiation in Ovariectomized Rats Fed Normal or High-fat Diets被引量：1
《Clinical Complementary Medicine and Pharmacology》2023年第3期1-7,共7页Xiwen Jia Simeng Guo Youling Huang Dongheng Zheng Yuqi Ding Xilin Qiao Zhishan Ding Yanfen Huang 
This project was financially supported by the Natural Science Foun-dation of China(Grant No:81303258).
Background:Our previous in vitro study has shown that total flavonoids from the leaves of Carya cathayensis exert estrogenic activities by promoting the expressions of ER𝛼and ER𝛽.C.cathayensis leaf extract(CCE)was r...
关键词：Hepatic lipogenesis Adipocyte differentiation OVARIECTOMY DYSLIPIDEMIA PHYTOESTROGENS 
Discovery of an orally effective double-stapled peptide for reducing ovariectomy-induced bone loss in mice被引量：2
《Acta Pharmaceutica Sinica B》2023年第9期3770-3781,共12页Wei Cong Huaxing Shen Xiufei Liao Mengjun Zheng Xianglong Kong Zhe Wang Si Chen Yulei Li Honggang Hu Xiang Li 
supported by Shanghai Rising-Star Program(to Xiang Li);the National Nature Science Foundation of China No.21807112(to Xiang Li),No.91849129(to Honggang Hu),No.22077078(to Honggang Hu)and No.22207065(to Yulei Li);academic promotion program of Shandong First Medical University(No 2019LJ003,China,to Yulei Li);Taishan Scholars Program(to Yulei Li)。
Stapled peptides with significantly enhanced pharmacological profiles have emerged as promising therapeutic molecules due to their remarkable resistance to proteolysis and performance to penetrate cells.The all-hydroc...
关键词：Stapled peptides OSTEOPOROSIS Orally effective Double-stapling 
Antifertility potential of leaves and seeds of Delonix regia in female rats
《Asian pacific Journal of Reproduction》2023年第3期117-123,I0001,I0002,共9页Garg Megha Sharma Aditi Choudhary Manjusha Kaur Prabhjeet 
Objective:To evaluate the antifertility activity of hydroalcoholic extract of Delonix regia(Boj.ex Hook.)Raf.leaves and seeds which are traditionally being used by Yanadi tribe to treat dysmenorrhea.Methods:Three expe...
关键词：Delonix regia ANTI-IMPLANTATION Early abortifacient ESTROGENIC Gulmohar OVARIECTOMY 
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