Lactobacillus plantarum CCFM1180 attenuates obesity induced by estrogen deficiency by activating estrogen receptor alpha in abdominal adipose tissue and regulating gut microbiota-derived metabolites  

作　　者：Qian Chen Chunxia Mei Min Guo Botao Wang Haiqin Chen Jianxin Zhao Gang Wang Wei Chen 

机构地区：[1]State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China [2]School of Food Science and Technology,Jiangnan University,Wuxi 214122,China [3]National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China [4](Yangzhou)Institute of Food Biotechnology,Jiangnan University,Yangzhou 225004,China [5]Bloomage Biotechnology Co.,Ltd.,Jinan 250000,China

出　　处：《Food Science and Human Wellness》2024年第2期765-777,共13页食品科学与人类健康（英文）

基　　金：funded by the National Natural Science Foundation of China(31972052,32021005,31820103010);the Fundamental Research Funds for the Central Universities(JUSRP22006,JUSRP51501);the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province。

摘　　要：Lipid metabolism disorders commonly occur during menopause.Estrogen deficiency has been shown to lead to excessive energy intake and abnormal lipid metabolism in ovariectomized rats,resulting in obesity.Probiotics exhibit anti-obesity properties,and their underlying mechanism has been widely reported.In this study,we demonstrated the metabolic benefits of Lactobacillus plantarum CCFM1180 in suppressing appetite,controlling body weight,correcting obesity-induced abnormalities,enhancing liver lipid metabolism,and protecting liver function in estrogen-deficient rats.The mechanisms associated with the anti-obesity and anti-dyslipidemia effects of CCFM1180 on estrogen-deficient rats were clarified.The results showed that CCFM1180 dramatically reduced food intake by activating the expression of estrogen receptor alpha(ERα)and increasing the level of leptin in abdominal adipose tissue.These changes,combined with the increased butyrate concentration and recovered bile acid structure,helped enhance lipid metabolism.Additionally,CCFM1180 treatment was found to be safer than exogenous estrogen supplementation.Thus,L.plantarum CCFM1180 could be considered a new therapeutic strategy for preventing and alleviating menopausal lipid abnormalities.

关 键 词：Bile acid Gut microbiota MENOPAUSE OVARIECTOMY Short chain fatty acid 

分 类 号：TS201.3[轻工技术与工程—食品科学]