Antifertility potential of leaves and seeds of Delonix regia in female rats  

作　　者：Garg Megha Sharma Aditi Choudhary Manjusha Kaur Prabhjeet 

机构地区：[1]Institute of Pharmaceutical Sciences,Kurukshetra University,Kurukshetra,India

出　　处：《Asian pacific Journal of Reproduction》2023年第3期117-123,I0001,I0002,共9页亚太生殖杂志（英文版）

摘　　要：Objective:To evaluate the antifertility activity of hydroalcoholic extract of Delonix regia(Boj.ex Hook.)Raf.leaves and seeds which are traditionally being used by Yanadi tribe to treat dysmenorrhea.Methods:Three experimental animal models,including anti-implantation,early abortifacient,and estrogenic activity in female rats,were used for evaluation of the antifertility activity of both extracts at two dose levels(250 and 500 mg/kg,orally).There were five groups in the anti-implantation and early abortifacient activity while six groups in estrogenic activity including the standard.The number of implants,resorptions,vaginal cornification,body weight,uterus weight,and biochemical parameters were measured.Results:At doses 250 and 500 mg/kg,the leaf extract was found to have strong anti-implantation action.The extract administered at the same doses also caused a significant rise in the number of resorptions,showing early abortifacient activity,increased uterine weight,and altered numerous biochemical parameters.Meanwhile,the seed extract only displayed slight anti-implantation activity at both levels.Conclusions:Based on these preliminary findings,we can conclude that the leaf extract outperformed the seed extract in terms of antifertility activity,exhibiting potent estrogenic,anti-implantation and early abortifacient activities in a dose-dependent manner.These findings are consistent with the literature study and corroborate to the antifertility activity of the plant.

关 键 词：Delonix regia ANTI-IMPLANTATION Early abortifacient ESTROGENIC Gulmohar OVARIECTOMY 

分 类 号：R285.5[医药卫生—中药学]