Perpyrrospirone A, an unprecedented hirsutellone peroxide from the marine-derived Penicillium citrinum  

作　　者：Yi Ding Yu Jiang Sunjie Xu Xiujuan Xin Faliang An 

机构地区：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China

出　　处：《Chinese Chemical Letters》2023年第2期463-467,共5页中国化学快报（英文版）

基　　金：funded by the National Natural Science Foundation of China (Nos. 41876189, 81703388);the National Key R&D Program of China (Nos. 2018YFC1706206, 2019YFC0312504);supported by the Open Research Fund Program of State Key Laboratory of Bioreactor Engineering and Institute of Regulatory Science。

摘　　要：Perpyrrospirone A(1) characterized an unprecedented 6/5/6/8/5/13/6 oxahexacyclic scaffold with a unique peroxide-bridged 8,9-dioxa-2-azaspiro[4.7]dodecane core from marine-derived Penicillium citrinum. Compounds 2 and 3 possessed rare oxatetracyclic(6/5/6/5) skeleton fused with a 13-menberedring macrocyclic moiety. Their structure and absolute configurations were determined by comprehensive spectroscopic analyses, ECD data coupled with TD-DFT calculations and X-ray diffraction experiments. In addition, 7 showed cytotoxicity and induced apoptosis of Hela cells in a dose-dependent manner after a48 h treatment.

关 键 词：Penicillium citrinum Hirsutellone PEROXIDE X-RAY CYTOTOXICITY 

分 类 号：R284[医药卫生—中药学]