含咪唑盐聚离子液体微凝胶的制备及其抗菌性能研究  

Preparation and antibacterial biological properties of poly(ionic liquid)micro-gels containing imidazolium salts

作　　者：孙梦迪 周超[2] 邓林红[1] 周鑫叠 黄勇 SUN Mengdi;ZHOU Chao;DENG Linhong;ZHOU Xindie;HUANG Yong(School of Pharmacy,Biology and Food Engineering,Changzhou University,Changzhou 213164,China;Institute of Biomedical Engineering and Health Sciences,Changzhou University,Changzhou 213164;Department of orthopedics,The Affiliated Changzhou Second People′s Hospital of Nanjing Medical University,Changzhou 213001)

机构地区：[1]常州大学药学院、生物与食品工程学院,常州213164 [2]常州大学医学与健康工程学院,常州213164 [3]南京医科大学附属常州第二人民医院骨科,常州213001

出　　处：《生物医学工程研究》2023年第1期73-81,共9页Journal Of Biomedical Engineering Research

基　　金：常州市科技计划项目(CJ20220120);超分子结构与材料国家重点实验室开放课题项目(sklssm2022037)。

摘　　要：大多数咪唑盐聚离子液体以线性聚合物的形式存在于抗菌材料中,将其制备成纳米颗粒形式可提高抗菌活性、降低细胞毒性。本研究采用乳液聚合法设计并制备了含咪唑盐聚离子液体的微凝胶,并将所制备的咪唑盐聚离子液体微凝胶与其相对应的线性聚合物进行对比。结果表明,微凝胶可有效提高聚合物的电负性,其对金黄色葡萄球菌的抑制率达到了99.8%,抗菌性能明显提高。本研究制备的含咪唑盐聚离子液体微凝胶具有高抗菌性以及低细胞毒性,可作为一种新型聚合物抗菌剂应用于生物医学材料中。At present,most imidazole poly(ionic liquids)exist in antibacterial materials as linear polymers,which can be prepared into nanoparticles to improve their antibacterial activity and reduce cytotoxicity.We designed an antibacterial micro-gel containing the imidazole salt poly(ionic liquid)by emulsion polymerization,and compared the micro-gel containing the imidazole salt poly(ionic liquid)with their corresponding linear polymers.The experimental results showed that the preparation of micro-gel could effectively improve the electronegativity of polymer,its inhibition rate of the micro-gel against staphylococcus aureus reached 99.8%,the antibacterial activity was enhanced.This micro-gel containing the imidazole salt poly(ionic liquid)exhibits high antibacterial activity and low cytotoxicity.It can be used as a new type of polymer antibacterial agent in biomedical materials.

关 键 词：咪唑盐聚离子液体 微凝胶 乳液聚合 电负性 抗菌活性 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程] TB234[医药卫生—基础医学]