女贞药用价值及其相关上市药品的研究进展  

Research progress on medicinal value of Ligustrum lucidum and related marketed drugs

作　　者：徐浩然 程国良 黄志伟 李冰 贾彬 李莎莎 金慧子[4] 王义忠 严诗楷 肖雪[1] XU Hao-ran;CHENG Guo-liang;HUANG Zhi-wei;LI Bing;JIA Bin;LI Sha-sha;JIN Hui-zi;WANG Yi-zhong;YAN Shi-kai;XIAO Xue(Institute of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine,Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276000,China;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China;College of Pharmacy,Shanghai Jiaotong University,Shanghai 200240,China)

机构地区：[1]广东药科大学中医药研究院,广东广州510006 [2]鲁南制药集团股份有限公司中药制药共性技术国家重点实验室,山东临沂276000 [3]广州中医药大学第二附属医院,广东广州510120 [4]上海交通大学药学院,上海200240

出　　处：《中草药》2023年第5期1663-1671,共9页Chinese Traditional and Herbal Drugs

基　　金：山东省重大科技创新工程(2021CXGC010508);广州市科技计划项目珠江科技新星专项(201610010113);国家药品监督管理局快速检验技术重点实验室开放课题(KF2022002);国家药品监督管理局快速检验技术重点实验室开放课题(KF2022006)。

摘　　要：女贞Ligustrum lucidum是木犀科女贞属药用植物,其果实、叶、花等部位均可作为药用。女贞不同药用部位及单体成分具有多种功效,现已开发为多种制剂,既有中药单方制剂,也有以单体成分为主的化学药。大量研究表明,女贞相关药品被广泛用于治疗消化系统、免疫系统等疾病,且临床效果较好。通过对女贞不同药用部位的化学成分、临床应用及药理作用、女贞相关上市药品的工艺与质量、临床应用及基础研究进行综述,进而探讨女贞的潜在应用价值和开发前景,为女贞的综合开发与利用提供一定的参考。Ligustrum lucidum is a medicinal plant of Ligustrum of the family Oleaceae,and its fruit,leaves,flowers and other parts are used for medicine.Different parts and monomeric components of Ligustrum lucidum.have a variety of effects,and have been developed into a variety of preparations,not only traditional Chinese medicine preparations,but also chemical drugs with monomeric components.Ligustrum lucidum associated drugs are mostly used to treat digestive system disease,immune system disease and other diseases,with good clinical effect.This paper summarized the chemical composition and pharmacological effects of different part of Ligustrum lucidum,its related listed pharmaceutical technology and quality,clinical practice and basic research,discusses the potential application value and development prospects of Ligustrum lucidum,for its comprehensive development and utilization to provide certain reference.

关 键 词：女贞 女贞子 女贞叶 齐墩果酸 熊果酸 质量标准 上市药品 综合开发 

分 类 号：R286[医药卫生—中药学]