六君子汤合旋覆代赭汤治疗反流性食管炎临床疗效及对HIF-2α/NF-κB信号通路的影响  

Clinical Efficacy of Liujunzi Decoction(六君子汤)Combined with Xuanfu Daizhe Decoction(旋覆代赭汤)Treating Reflux Esophagitis and Its Effect on HIF-2α/NF-κB Signaling Pathway

作　　者：崔亚 邓海鹏 焦黛妍 CUI Ya;DENG Haipeng;JIAO Daiyan(Department of Traditional Chinese Medicine Rehabilitation,Haian People's Hospital,Haian 226600,Jiangsu,China)

机构地区：[1]海安市人民医院中医康复科,江苏海安226600

出　　处：《辽宁中医杂志》2023年第1期58-62,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：江苏省南通市科技计划项目(MSZ21093);国家自然科学基金项目(81673736)。

摘　　要：目的探讨六君子汤合旋覆代赭汤治疗反流性食管炎(RE)临床疗效及对HIF-2α/NF-κB信号通路的影响。方法选取RE中虚气逆证患者给予六君子汤合旋覆代赭汤口服(并设西药对照组),观察两组治疗前后临床症状积分变化、血浆HIF-2α、NF-κB、TRPV1及炎症因子水平变化,并对比停药后复发情况。结果两组患者治疗后典型反流症状积分及中医主次症评分均下降(P<0.05),中药组除烧心、胃脘隐痛症状外,各项评分下降更显著(P<0.05);两组临床症状积分总分均较治疗前明显降低,中药组下降更明显(P<0.05);中药组总有效率高于西药组(P<0.05);中药组停药3个月后复发率低于西药组(P<0.05);两组HIF-2α、NF-κB p65、TRPV1水平均较治疗前降低,中药组NF-κB p65下降更明显(P<0.05);两组血浆炎症因子水平均较治疗前降低,中药组IL-6、IL-8、IL-9及TNF-α水平下降更显著(P<0.05)。结论六君子汤合旋覆代赭汤与西药对照组相比,可显著改善RE中虚气逆证患者临床症状,疗效显著,且能降低RE复发率,其机制可能与下调HIF-2α、NF-κB及TRPV1表达,改善食道黏膜炎症状态下缺氧微环境变化,降低食管高敏感性有关。Objective To assess the clinical efficacy of Liujunzi Decoction(六君子汤)combined with Xuanfu Daizhe Decoc⁃tion(旋覆代赭汤)in the treatment of reflux esophagitis(RE)and its effect on human hypoxia inducible factor 2(HIF-2)al⁃pha/nuclear factor kappa-B(NF-κB)signaling pathway.Methods RE patients with deficiency of Qi and reverse syndrome were selected to take Liujunzi Decoction combined with Xuanfu Daizhe Decoction(western medicine control group was also set up).The changes of clinical symptom scores and the levels of HIF-2α,NF-κB,transient receptor potential vanilloid-1(TRPV1)and inflammatory factors were compared before and after treatmen,and the recurrence was compared after stopping the drug.Re⁃sults After treatment,the scores of typical reflux symptoms and primary and secondary symptoms of traditional Chinese medicine decreased in both groups and those of the traditional Chinese medicine group decreased more significantly except the symptoms of heartburn and stomach pain(P<0.05).The total scores of clinical symptoms in the two groups were significantly lower and the scores of the traditional Chinese medicine group decreased more obviously(P<0.05).The total effective rate of the traditional Chinese medicine group was higher than that of the western medicine control group(P<0.05).The recurrence rate of the tradi⁃tional Chinese medicine group was lower than that of the western medicine control group after 3 months of discontinuation(P<0.05).The levels of HIF-2α,NF-κB p65 and TRPV1 in the two groups were lower than those before treatment,and the tradi⁃tional Chinese medicine group had lower levels of NF-κB p65(P<0.05).The levels of plasma inflammatory factors in both groups were lower after treatment(P<0.05),and the levels of interleukin(IL)-6,IL-8,IL-9 and tumor necrosis factor-α(TNF-α)were significantly lower than those of the western medicine control group(P<0.05).Conclusion Liujunzi Decoction combined with Xuanfu Daizhe Decoction can significantly improve the clinical symptoms and r

关 键 词：六君子汤 旋覆代赭汤 缺氧诱导因子-2Α 核转录因子-ΚB 辣椒素受体1 炎症因子 

分 类 号：R571[医药卫生—消化系统]