植物适应性原:治疗病毒感染后疲劳有前途的治疗分子  

Plant adaptive agents: promising therapeutic molecules in the treatment of post-viral fatigue

作　　者：晏一淇 韩睿[1,2,3] 马耀磊 张晗[1,2,3] Patrick Kwabena Oduro 王小莹[5] 雷伟[1,2,3] Yiqi Yan;Rui Han;Yaolei Ma;Han Zhang;Patrick Kwabena Oduro;Xiaoying Wang;Wei Lei(Laboratory of Pharmacology of Traditional Chinese Medicine Formulae Co-Constructed by the Province-Ministry,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory of Component Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Jacobs School of Medicine and Biomedical Sciences,University at Buffalo,State University of New York,New York,NY,USA;不详)

机构地区：[1]省部共建中药方剂药理学实验室,天津中医药大学,天津301617 [2]天津中医药大学中药成分国家重点实验室,天津301617 [3]天津中医药大学中医药研究所,天津301617 [4]美国纽约州立大学布法罗大学雅各布斯医学和生物医学科学学院 [5]中国天津中医药大学中药学院,天津301617

出　　处：《Acupuncture and Herbal Medicine》2023年第1期20-27,共8页针灸和草药（英文）

基　　金：Tianjin Science and Technology Plan Project:Study on the action mechanism of Traditional Chinese Medicine against new coronavirus(Omicron)(22ZXGBSY00020);2022 Chinese Medicine Clinical Efficacy Improvement Project of the State Administration of Traditional Chinese Medicine.

摘　　要：近年来,通过全国性的预防和控制措施,有效控制了新型冠状病毒肺炎(COVID-19)在中国的传播。然而,大量康复患者受到疲劳的困扰,无论是急性还是慢性的,以及其他严重影响生活质量的与疲劳相关的综合症。病毒感染后疲劳综合症(PVFS)是一种广泛存在的慢性神经系统疾病,缺乏明确的病因因素、确切的诊断检测方法或经批准的药物治疗、疗法或治愈方案。本研究通过文献计量学分析结果表明,神经炎症在PVFS的发展中发挥了作用。因此,本研究简要分析了COVID-19患者神经炎症发展的机制。为了寻找缓解PVFS的有效药物,我们总结了四种传统草药的适应症,并讨论了它们在改善神经疲劳方面的分子机制。研究表明,人参、刺五加、红景天和五味子在缓解PVFS方面具有益处。In recent years,the spread of the coronavirus disease 2019(COVID-19)in China has been effectively controlled by implementing national prevention and control measures.However,a large number of recovered patients are plagued by fatigue,whether acute or chronic,and other fatigue-related syndromes that severely affect their quality of life.Post-viral fatigue syndrome(PVFS)is a widespread chronic neurological disease with no definite etiological factor(s),definitive diagnostic test,or approved pharmacological treatment,therapy,or cure.In this study,we performed a bibliometric analysis and the results suggested that neuroinflammation played a role in the development of PVFS.Therefore,we briefly analyzed the mechanisms underlying the development of neuroinflammation in patients with COVID-19.To identify effective drugs to alleviate PVSF,we summarized four traditional herbal phytoadaptations and discussed their molecular mechanisms in improving neurological fatigue.Our study showed that ginseng,Acanthopanax,Rhodiola,and Schisandra played beneficial roles in alleviating PVSF.

关 键 词：病毒后疲劳综合症 长期新冠感染 适应原 疲劳 中医药 新冠病毒 

分 类 号：R73[医药卫生—肿瘤]