正念认知治疗联合度洛西汀对躯体形式障碍患者的效果  

The efficacy of mindfulness⁃based cognitive therapy combined with duloxetine for patients with somato⁃form disorder

作　　者：李媛媛[1] 王策 丁晓超 于雪竹[1] 刘杰[1] 刘卓威 LI Yuanyuan;WANG Ce;DING Xiaochao;YU Xuezhu;LIU Jie;LIU Zhuowei(Hebei Provincial Mental Health Center,Hebei Key Laboratory of Major Mental and Behavioral Disorders,the Sixth Clinical Medical College of Hebei University,Baoding 071000,China)

机构地区：[1]河北省精神卫生中心、河北省重大精神与行为障碍疾病研究重点实验室、河北大学第六临床医学院,河北保定071000

出　　处：《实用医学杂志》2023年第5期613-618,共6页The Journal of Practical Medicine

基　　金：2021年度河北省医学科学研究课题计划(编号:20210184)。

摘　　要：目的 评价正念认知治疗联合度洛西汀对躯体形式障碍患者的疗效。方法 将符合入组标准的80例患者随机分为联合治疗组(n=38)及单药治疗组(n=42),治疗周期为8周,分别在基线期、治疗后2、4、6、8周采用五因素正念量表(five facet mindfulness questionaire,FFMQ)、汉密尔顿焦虑量表(hamilton anxiety scale,HAMA)评估患者正念技能及焦虑症状改善的效果。结果 重复测量方差分析结果显示:联合治疗组正念技能提高较明显,两组间差异有统计学意义(F=96.462,P <0.001);联合治疗组中高学历组较低学历组正念技能提高较多,差异有统计学意义(F=34.485,P <0.001);联合治疗组FFMQ各维度评分随着时间的延长均显著提高,差异有统计学意义(P <0.001)。疗效方面,联合治疗组患者的焦虑症状更早得到缓解。结论 正念认知治疗联合度洛西汀能明显改善躯体形式障碍患者的正念技能及焦虑症状。Objective To evaluate the efficacy of combination therapy of mindfulness⁃based cognitive thera⁃py(MBCT)and duloxetinein patients with somatoform disorder.Methods This was an 8⁃weeks randomized control study.Totally 80 patients with somatoform disorder who met the criteria for inclusion were recruited.All patients were randomly assigned to one of two groups:MBCT and Duloxetine treatment(n=38)or Duloxetine control(n=42).The Five Facet Mindfulness Questionaire(FFMQ)and Hamilton Anxiety Scale(HAMA)were administered to evalu⁃ate the improvement effect of mindfulness skills and anxiety symptoms.Results ANOVA for repeated measurement results showed that the mindfulness skills of the combined treatment group were significantly improved,and the dif⁃ferences were statistically significant(F=96.462,P<0.001).In the combined treatment group,the mindfulness skills of the higher education group were improved more than those of the lower education group,and the differences were statistically significant(F=34.485,P<0.001).The scores of each dimension of FFMQ in the combined treat⁃ment group were significantly improved with the extension of time,and the differences were statistically significant.In terms of efficacy,anxiety was relieved earlier in the combined treatment group.Conclusion MBCT combined with duloxetine can significantly improve mindfulness skills and anxiety symptoms.

关 键 词：正念认知治疗 度洛西汀 躯体形式障碍 效果 

分 类 号：R749[医药卫生—神经病学与精神病学]