p53信号通路调控铁死亡在肝细胞癌中的作用机制  

The mechanism of p53 signaling pathway regulating ferroptosis in hepatocellular carcinoma

作　　者：李震 刘江凯[2] LI Zhen;LIU Jiangkai(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000,China;Department of Hepatology and Spleen-Stomach,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一临床医学院,郑州450000 [2]河南中医药大学第一附属医院脾胃肝胆科,郑州450000

出　　处：《临床肝胆病杂志》2023年第4期956-960,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(联合基金)(U1504825);河南省高等学校重点科研项目(20A360014);河南省中医药拔尖人才培养项目资助(豫卫中医函〔2021〕15号)。

摘　　要：肝细胞癌(HCC)在我国是最常见的肝癌类型,其发生发展是一个复杂的病理过程。铁死亡作为一种新的细胞死亡方式,在治疗HCC方面有巨大的潜在作用。本文介绍了抑癌因子p53在调控铁死亡中的作用机制,简述其在HCC发生、发展中的作用。抑癌因子p53可以通过影响溶质载体家族7成员11、亚精胺/精胺N1-乙酰转移酶1、谷氨酰胺酶2、二肽基肽酶4和细胞周期蛋白依赖性激酶抑制剂1A来促进或抑制铁死亡,进而影响HCC的进展,通过调控铁死亡通路治疗HCC具有很大的应用前景。Hepatocellular carcinoma(HCC)is the most common type of liver cancer in China,and the development and progression of HCC is a complex pathological process.As a new way of cell death,ferroptosis has huge potential in the treatment of HCC.This article introduces the mechanism of action of the tumor suppressor p53 in regulating ferroptosis and briefly describes its role in the development and progression of HCC.The tumor suppressor p53 can promote or inhibit ferroptosis by affecting solute carrier family 7 member 11,spermidine/spermine N1-acety-ltransferase 1,glutaminase 2,dipeptidyl peptidase 4,and cyclin-dependent kinase inhibitor 1A,which in turn affects the progression of HCC.The treatment of HCC by regulating the ferroptosis pathway has great application prospects.

关 键 词：铁死亡 癌 肝细胞 肿瘤抑制蛋白质P53 

分 类 号：R735.7[医药卫生—肿瘤]