基于文献计量学分析缺血性脑血管病预后的基因组学研究  

The Bibliometrics-based Genomics Studies on Prognosis of Ischemic Cerebrovascular Disease

作　　者：勾岚 许喆 李兰欣 石延枫 刘阳 赵曼曼[2,3] 李昊 程丝 GOU Lan;XU Zhe;LI Lanxin;SHI Yanfeng;LIU Yang;ZHAO Manman;LI Hao;CHENG Si(The Fifth Clinical College of Medicine,Capital Medical University,Beijing 100070,China;Center of Excellence for Omics Research,China National Clinical Research Center for Neurological Diseases,Beijing 100070,China;The Fourth Clinical College of Medicine,Capital Medical University,Beijing 100176,China;Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Clinical Center for Precision Medicine in Stroke,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学第五临床医学院,北京100070 [2]国家神经系统疾病临床医学研究中心卒中多组学创新中心,北京100070 [3]首都医科大学第四临床医学院,北京100070 [4]首都医科大学附属北京天坛医院神经病学中心,北京100070 [5]首都医科大学卒中精准临床诊疗与研究中心,北京100070

出　　处：《中国卒中杂志》2023年第3期266-272,共7页Chinese Journal of Stroke

基　　金：国家重点研发计划资助项目(2022YFE0209600);国家自然科学基金青年科学基金项目(82101359)。

摘　　要：目的分析2017—2022年缺血性脑血管病(ischemic cerebrovascular disease,ICVD)预后的基因组学研究现状、研究热点及前沿领域。方法在WebofScience核心合集(SCI-EXPANDED)中检索2017年1月1日—2022年10月1日ICVD预后的基因组学相关文献。使用CiteSpace软件分析文献中发文国家、机构、作者间的合作网络;参考文献、参考文献第一作者、期刊的共被引网络;参考文献的聚类结果;关键词的共现网络及其聚类结果,并使用可视化图谱呈现结果。结果共纳入353篇文献。中国发文144篇,居全球首位,但仅与5个国家建立了合作关系。首都医科大学是发文最多的机构,共20篇。国际卒中遗传学联盟成员在发文量前10位的作者中占据6位,是发文的主力军并形成了主要的合作团簇。研究方法多使用全基因组关联分析和孟德尔随机化。近年来的研究热点是探究卒中预后与其他复杂疾病的共同遗传通路、影响抗血小板药物疗效的遗传变异,以及炎症机制在预后中的影响。结论ICVD预后的基因组学研究热度逐年上升,已形成多个研究热点,主要探索相关潜在机制来推动新药研发。Objective To analyze the current research status,hotspots,and frontier fields of genomics studies on the prognosis of ischemic cerebrovascular disease(ICVD)from 2017 to 2022.Methods The related English literature of genomics in the field of ICVD was retrieved in the Web of Science Core Collection(SCI-EXPANDED)from January 1,2017 to October 1,2022.CiteSpace software was used to analyze the cooperation network among the publishing countries,institutions and authors;the co-citation network of reference,first author of reference and journals;clustering randomization were the most commonly used research methods.In recent years,the hotspots focused on exploring the common genetic pathways of stroke prognosis and other complex diseases,genetic variation affecting the efficacy of antiplatelet drugs,and the influence of inflammatory mechanism on prognosis.Conclusions The genomics studies of ICVD prognosis,which explore the underlying mechanism to facilitate new drugs development,have gained the popularity year by year and formed several research hotspots.

关 键 词：缺血性脑血管病 预后 基因组学 文献计量学 

分 类 号：R743.3[医药卫生—神经病学与精神病学] G353.1[医药卫生—临床医学]