生物墨水挤出打印成型精度评价方法概述  

Overview of methods for evaluating accuracy of bioink extrusion bioprinting

作　　者：林泽宁 蒋涛 尚建忠[1] 杨云 洪阳 罗自荣 LIN Ze-ning;JIANG Tao;SHANG Jian-zhong;YANG Yun;HONG Yang;LUO Zi-rong(College of Intelligence Science and Technology,National University of Defense Technology,Changsha 410073,China)

机构地区：[1]国防科技大学智能科学学院,湖南长沙410073

出　　处：《浙江大学学报（工学版）》2023年第4期643-656,共14页Journal of Zhejiang University：Engineering Science

基　　金：国家自然科学基金资助项目(52105039);湖南省研究生科研创新资助项目(CX20220027);国防科技大学科研计划资助项目(ZK-19);国防科技大学智能科学学院青年骨干教师资助项目(4142Z6G2)。

摘　　要：为了推动挤压生物3D打印结构精度的提升,介绍了以水凝胶为代表的生物墨水挤压打印原理及相关数学模型.针对打印精度的影响因素,从结构设计、生物墨水特性、打印设备及工艺参数三方面进行系统分析,总结各参数对打印精度的作用.按照定量评价方法所涉及参数的维度归纳总结并分析不同方法的优缺点,从仿真预测、克服材料力学行为、辅助打印等方面提出研究思路,为后续挤压生物3D打印技术的进一步发展提供参考.The principle of extrusion-based bioprinting with bioinks represented by hydrogels and the related mathematical model were introduced in order to improve the accuracy of extrusion-based 3D bioprinting structure.The factors affecting the printing accuracy were systematically analyzed in terms of structural design,bioink properties,bioprinting equipment and technological parameters,and the role of each parameter on the printing accuracy was summarized.The advantages and disadvantages of different methods were analyzed based on the dimensions of the parameters involved in the quantitative evaluation methods.Research ideas from simulation prediction,overcoming material mechanical behaviors and assisted printing were proposed,which provided references for the further development of the extrusion-based 3D bioprinting technology.

关 键 词：挤压生物3D打印 打印精度 结构设计 生物墨水特性 工艺参数 定量打印评价方法 

分 类 号：TH164[机械工程—机械制造及自动化]