硬脂酰辅酶A去饱和酶1在恶性肿瘤中的研究进展  

Research advances in role of SCD1 in tumors

作　　者：张寰[1] 高云鹤[1] 杨华夏[1] 夏绍友[1] 陈凛[1] ZHANG Huan;GAO Yunhe;YANG Huaxia;XIA Shaoyou;CHEN Lin(Department of General Surgery,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心普通外科医学部,北京100853

出　　处：《解放军医学院学报》2023年第2期187-190,196,共5页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(81972790)。

摘　　要：恶性肿瘤的特点之一是不受控制地增殖和生长,该过程需要大量的能量和物质作为基础。这需要肿瘤在糖脂代谢上作出改变,以适应增殖和生长的需要。恶性肿瘤的脂代谢改变除了能为生长提供能量和物质基础,其中一些脂质也是细胞信号通路中的重要分子。脂代谢中的关键酶硬脂酰辅酶A去饱和酶1(stearoyl-CoA desaturase-1,SCD1)在其中发挥了重要作用。本文旨在对SCD1的作用、SCD1在人体组织内分布、SCD1与恶性肿瘤的关系、SCD1靶向抑制剂研究进展等进行综述。One of the characteristics of malignant tumors is the uncontrolled proliferation and growth,and this process demands a large amount of energy and matter as a foundation.It also requires changes in the glucose metabolism and lipid metabolism of the tumor to adapt to the needs of proliferation and growth.Besides providing energy and material basis for the growth of malignant tumors,lipid is also an important molecule in cell signaling pathway.Stearoyl-coa desaturase-1,a key enzyme in lipid metabolism,has played an important role in malignant tumors.The purpose of this review is to review SCD1’s function,location,the relationship of SCD1 and tumor,and research advances in inhibitors of SCD1.

关 键 词：恶性肿瘤 硬脂酰辅酶A去饱和酶1 硬脂酰辅酶A去饱和酶1抑制剂 脂代谢 靶向治疗 

分 类 号：R73[医药卫生—肿瘤]