Serum metabolic effects of corn oligopeptides with 7-day supplementation on early post-surgery primary liver cancer patients: a double-blind randomized controlled trial  

作　　者：Weiqi Rong Hui Xia Kai Zhang Yihan Zhang Changcheng Tao Fan Wu Liming Wang Hong Zhang Guiju Sun Jianxiong Wu 

机构地区：[1]Department of Hepatobiliary Surgery,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC),Beijing,China [2]Key Laboratory of Environmental Medicine and Engineering of Ministry of Education,Department of Nutrition and Food Hygiene,School of Public Health,Southeast University,Nanjing,China [3]Department of Interventional Therapy,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin’s Clinical Research Center for Cancer,Tianjin,China

出　　处：《Hepatobiliary Surgery and Nutrition》2022年第6期834-847,共14页肝胆外科与营养（英文）

基　　金：We sincerely thank all support from National Key Research and Development Program of China(No.2016YFD0400604).

摘　　要：Background:Liver cancer as the main leading cancer has caused heavy burdens globally.The prognosis of liver cancer is closely related with postoperative nutrition support.Corn oligopeptides(COPs)are protein hydrolysates produced by enzymatic treatments,which have shown potential bioactivities,such as inhibiting angiotensin I-converting enzyme,resisting lipid peroxidation and anti-oxidant.However,the correlation between COPs and liver cancer patients is still unknown and the potential mechanism of COPs on liver cancer is unclear as well.The aim of this study was to assess effects of 7-day intervention of COPs after surgery on liver function and serum metabolic profiles of liver cancer patients.Methods:Patients were assigned into COPs intervention group(n=50)and control group(n=91)for 7 days.Investigations were scheduled at 1st day and 7th day after liver resection surgery respectively,mainly including anthropometric,biochemical indexes and liquid chromatography-mass spectrometry(LC/MS)analysis.Results:Seven-day supplementation of COPs on early post-surgery liver cancer patients down-regulated levels of alanine aminotransferase,aspartate aminotransferase,total bilirubin,direct bilirubin and up-regulated prothrombin time activity and prealbumin levels.LC/MS analysis revealed metabolic signatures including regulation of 16 metabolites,which was closely related with two metabolic pathways(nicotinate and nicotinamide metabolism,fatty acid metabolism).Conclusions:COPs supplementation has displayed the potentials on alleviating the injury of liver function and it may be due to regulation of fatty acid metabolism,nicotinate and nicotinamide metabolism,lipid peroxidation and anti-inflammatory action.More researches are warranted in future to confirm the exact mechanisms.

关 键 词：Liver cancer corn oligopeptides supplementation metabolomics randomized controlled trial 

分 类 号：R730.56[医药卫生—肿瘤]