胃癌基础与转化研究的热点问题  

Hotspots in basic and translational research of gastric cancer

作　　者：李建芳[1] 余俊贤 严超[1] 朱正纲[1] 刘炳亚[1] LI Jianfang;YU Junxian;YAN Chao;ZHU Zhenggang;LIU Bingya(Department of General Surgery,Shanghai Institute of Digestive Surgery,Shanghai Key Laboratory of Gastric Neoplasms,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院普外科、上海消化外科研究所、上海市胃肿瘤重点实验室,上海200025

出　　处：《外科理论与实践》2023年第1期7-16,共10页Journal of Surgery Concepts & Practice

摘　　要：胃癌的发病率、死亡率均较高,而胃癌的总体疗效不满意。临床上面临的早期诊断率低、肿瘤异质性、缺乏精确分型和精准治疗方案、治疗抵抗、复发与转移等问题是胃癌总体疗效不高的关键所在。为根本解决上述临床问题,需加强胃癌的基础研究,包括肿瘤基因组学、基因编辑、肿瘤微环境、炎症和衰老与肿瘤的关系、细胞分化障碍、细胞自噬与死亡、代谢紊乱、免疫治疗和药物开发等核心命题。本文将概述临床上胃癌治疗所面临的问题,并阐述针对这些临床问题的基础研究重点领域,为胃癌基础及转化研究提供思路。The morbidity and mortality of gastric cancer are high,while the overall therapeutic effect is poor without satisfactory.Clinical obstacles,such as low early-diagnosis rate,tumor heterogeneity,lack of accurate classification and precise treatment,therapeutic resistance,recurrence and metastasis,are the key point issues to the lower efficacy in treatment of gastric cancer.In order to solve these clinical problems,it is necessary to devote more energy to the basic research of gastric cancer,including tumor genomics;gene editing;tumor microenvironment;inflammation,aging and tumor;cell differentiation disorders;autophagy and cell death;metabolic disorders;immunotherapy and drug development.This paper will summarize the clinical obstacles in the treatment of gastric cancer,and describe the directions of basic research on these clinical problems in future,so as to provide notions for the translational research of gastric cancer.

关 键 词：胃癌 转化医学 基因组学 免疫治疗 

分 类 号：R735.2[医药卫生—肿瘤]