中心体在免疫细胞功能和相关疾病中的作用及研究进展  

Recent Advances in the Role of the Centrosome in Immune Cells and Associated Diseases

作　　者：贺鹏翼 任超[1] 姚咏明[1] HE Peng-Yi;REN Chao;YAO Yong-Ming(Translational Medicine Research Center,Medical Innovation Research Division of the Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院医学创新研究部转化医学研究中心,北京100853

出　　处：《生理科学进展》2023年第2期134-140,共7页Progress in Physiological Sciences

基　　金：国家自然科学基金重点项目(81730057,82130062)资助课题。

摘　　要：中心体位于真核细胞核周,是细胞的微管组织中心。中心体参与细胞诸多生理过程,维持其稳态对防止多种人类疾病的发生具有重要意义。除在细胞分裂、细胞运动和细胞极性中发挥作用外,中心体亦参与机体免疫应答和多种炎症性疾病过程。本文拟就中心体在免疫细胞功能与相关疾病中的主要功能和信号通路做一综述,为进一步探究其免疫效应及调节机制提供参考。The centrosome,located in the perinuclear region of eukaryotic cells,serves as the major microtubule organizing center.It has been documented that centrosomes appear to be involved in many physiological processes,whose homeostasis prevents the onset of multiple diseases.Apart from their roles in cell division,motility,and polarity,centrosomes are also involved in the host immune response and a diverse range of inflammatory diseases.In this article,we will review the main functions and signaling pathways involving the centrosomes in immune cells and associated diseases,providing a reference for further investigation into their immunological effects and regulatory mechanisms.

关 键 词：中心体 免疫反应 免疫突触 信号转导 疾病 

分 类 号：R363[医药卫生—病理学] R34[医药卫生—基础医学]