Antidepressant-like Effects of Flavonoids from Pteridium aquilinum var.latiusculum  

作　　者：Zimeng FENG Xiang HAN Shuangli LIU Xiaohui WANG 

机构地区：[1]Research Center of Agricultural Environment and Resources,Jilin Academy of Agricultural Sciences,Changchun 130033,China [2]National&Local Joint Engineering Research Center for Ginseng Breeding and Application,Jilin Agricultural University,Changchun 130033,China

出　　处：《Medicinal Plant》2023年第1期55-63,共9页药用植物：英文版

基　　金：Supported by the Innovation Project of Jilin Academy of Agricultural Sciences(cxgc2017zy011);Major Project of Jilin Province Science and Technology Department(20170204046ny).

摘　　要：[Objectives]To explore the antidepressant-like effects of PAFL and its potential mechanisms.[Methods]This study used PAFL in mice under various conditions and analyzed the results.The antidepressant-like effects of flavonoids from Pteridium aquilinum(PAFL)and its possible action mechanism were discussed.[Results]PAFL(5 mg/kg,i.p.)exhibited markedly antidepressant-like activities,which could be reversed by treatment with p-chlorophenylalanine(an inhibitor of 5-HT synthesis),haloperidol(a non-selective D 2 receptor antagonist)and N-methyl-D-aspartic acid(an agonist at the glutamate site).Meanwhile,PAFL also effectively increased the hippocampus 5-HT,DA,and Glu levels of mice exposed to TST and FST.The LPS-induced antidepressant behavioral experiment showed that PAFL(1 and 5 mg/kg,i.p.)and fluoxetine(20 mg/kg,i.p.)effectively reduced the immobility time,and increase activity time in OFT.PAFL pretreatment significantly reduced IL-6 and TNF-αserum levels and improve the changes of hippocampal SOD and MDA oxidative stress indicators.Furthermore,PAFL preconditioning could up-regulate BDNF and TrκB contents in hippocampus and down-regulate IκB-αand NF-κB phosphorylation.[Conclusions]The antidepressant-like effects of PAFL might be mediated by the 5-HT,DAergic and Gluergic systems,and the mechanisms of anti-depressant effects of PAFL might be via the alterations of animal behaviors,hippocampus inflammation and neurotrophy,which might be attributed by the BDNF/TrκB/NF-κB signaling pathway.

关 键 词：Pteridium aquilinum var.latiusculum Central nervous system LPS-induced depression Inflammation NEUROTROPHY 

分 类 号：R285.5[医药卫生—中药学]