摩罗丹辅助常规西药治疗慢性萎缩性胃炎疗效观察及对EGF、EGFR水平的影响  

Curative Observation of Moluo Pills Combined with Routine Western Medicine for Chronic Atrophic Gastritis and Its Effect on EGF and EGFR

作　　者：徐芳[1] 朱雅碧[1] 王立明[1] 尚惺杰[1] XU Fang;ZHU Yabi;WANG Liming;SHANG Xingjie

机构地区：[1]丽水市人民医院消化内科,浙江丽水323000

出　　处：《新中医》2023年第6期54-58,共5页New Chinese Medicine

摘　　要：目的:观察摩罗丹辅助常规西药治疗慢性萎缩性胃炎(CAG)的临床疗效及其对表皮生长因子(EGF)、表皮生长因子受体(EGFR)水平的影响。方法:将80例慢性萎缩性胃炎患者按随机数字表法分为治疗组与对照组各40例。对照组给予常规西药治疗,治疗组在对照组的基础上联合摩罗丹辅助治疗。2组均以1个月为1个疗程,连续治疗3个疗程后评估临床疗效、中医证候评分、血清EGF水平、胃黏膜EGFR阳性率及药物不良反应发生率。结果:治疗组总有效率为92.50%,高于对照组70.00%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组胃脘胀满、胃脘疼痛、胸胁胀痛、纳差、口干口苦等中医证候评分比较,差异无统计学意义(P>0.05);治疗后,2组上述各项证候评分均较治疗前降低(P<0.05),且治疗组各项评分均低于对照组(P<0.05)。治疗前,2组血清EGF水平比较,差异无统计学意义(P>0.05);治疗后,2组EGF水平较治疗前降低(P<0.05),且治疗组EGF水平低于对照组(P<0.05)。治疗前,2组胃黏膜EGFR阳性率比较,差异无统计学意义(P>0.05);治疗后,2组EGFR阳性率较治疗前降低(P<0.05),且治疗组EGFR阳性率低于对照组(P<0.05)。治疗组不良反应发生率为7.50%,对照组为10.00%,2组比较,差异无统计学意义(P>0.05)。结论:摩罗丹辅助常规西药治疗CAG疗效显著,有利于减轻患者临床症状,降低血清EGF及胃黏膜EGFR表达水平,且用药安全性良好。Objective: To observe the clinical effect of Moluo Pills combined with routine western medicine for chronic atrophic gastritis(CAG) and its effects on epidermal growth factors(EGF) and epidermal growth factor receptors(EGFR). Methods:A total of 80 cases of CAG patients were divided into the control group and the treatment group according to the random number table method, with 40 cases in each group. The control group was treated with routine western medicine, and the treatment group was additionally treated with Moluo Pills based on the treatment of the control group. Both groups were treated for three courses,with one month being one course. After treatment,clinical effects,traditional Chinese medicine syndrome scores,levels of EGF in serum,the positive rates of EGFR in gastric mucosa,and the incidence of adverse reactions were evaluated. Results:The total clinical effective rate was 92.50% in the treatment group, better than that of 70.00% in the control group, the difference being significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of scores of distention and fullness in the gastric cavity,pain in the gastric cavity,distending pain in the chest and ribside,poor appetite,and dryness and bitter taste in the mouth between the two groups(P>0.05);after treatment, the above syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and each score in the treatment group was lower than that in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of serum EGF levels between the two groups(P>0.05);after treatment, EGF levels in the two groups were decreased when compared with those before treatment(P<0.05), and the level in the treatment group was lower than that in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of the positive rates of EGFR in gastric mucosa between the two groups(P>0.05);after treatment,the

关 键 词：慢性萎缩性胃炎 摩罗丹 表皮生长因子 表皮生长因子受体 

分 类 号：R573.32[医药卫生—消化系统]