六君祛痰解毒汤联合化疗治疗非小细胞肺癌临床研究  

Clinical Study on Liujun Qutan Jiedu Decoction Combined with Chemotherapy for Non-Small Cell Lung Cancer

作　　者：郭桂明 王卫华 王小利 GUO Guiming;WANG Weihua;WANG Xiaoli

机构地区：[1]联勤保障部队第九八九医院肿瘤科,河南洛阳471000

出　　处：《新中医》2023年第6期132-135,共4页New Chinese Medicine

摘　　要：目的:观察六君祛痰解毒汤联合化疗治疗非小细胞肺癌的临床疗效及其对血管内皮生长因子(VEGF)的影响。方法:选取70例非小细胞肺癌患者,随机分为对照组和观察组各35例。对照组采用注射用盐酸吉西他滨+顺铂治疗,观察组在对照组的基础上加用六君祛痰解毒汤治疗。3周为1个疗程,共治疗2个疗程。比较2组临床疗效、不良反应发生率,以及治疗前后卡氏评分(KPS)、VEGF水平变化。结果:观察组总有效率为80.00%,对照组为57.14%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组KPS评分比较,差异无统计学意义(P>0.05);治疗后,2组KPS评分均较治疗前显著升高(P<0.05),且观察组KPS评分显著高于对照组(P<0.05)。治疗前,2组血清VEGF水平比较,差异无统计学意义(P>0.05);治疗后,观察组VEGF水平较治疗前及对照组降低(P<0.05),而对照组VEGF水平治疗前后比较,差异无统计学意义(P>0.05)。治疗过程中,观察组白细胞计数减少、血小板计数减少、胃肠道反应、贫血等比率分别为20.00%、5.71%、20.00%、14.29%,对照组分别为34.29%、22.86%、40.00%、34.29%,2组比较,差异均有统计学意义(P<0.05);观察组肝肾功能损伤发生率为11.43%,对照组为14.29%,组间比较,差异无统计学意义(P>0.05)。结论:六君祛痰解毒汤联合化疗治疗非小细胞肺癌可提高临床疗效,有效下调血清VEGF水平,改善患者生活质量,降低不良反应发生率。Objective: To observe the clinical effect of Liujun Qutan Jiedu Decoction combined with chemotherapy for non-small cell lung cancer(NSCLC) and its effect on vascular endothelial growth factor(VEGF). Methods:A total of 70 cases of NSCLC patients were randomly divided into the control group and the observation group, with 35 cases in each group. The control group was treated with Gemcitabine Hydrochloride and Cisplatin for injection, and the observation group was additionally treated with Liujun Qutan Jiedu Decoction based on the treatment of the control group. Both groups were treated for 2 courses,with 3 weeks being a course. The changes in Karnofsky Performance Status(KPS) scores and VEGF levels before and after treatment, the clinical effects and the incidence of adverse reactions were compared between the two groups. Results: The total effective rate was 80.00% in the observation group and57.14% in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of KPS scores between the two groups(P>0.05). After treatment,KPS scores in the two groups were significantly increased when compared with those before treatment(P<0.05),and KPS score in the observation group was significantly higher than that in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of serum VEGF between the two groups(P>0.05). After treatment,VEGF level in the observation group was decreased when compared with that before treatment and that in the control group(P<0.05);there was no significant difference being found in the comparison of VEGF levels before and after treatment in the control group(P>0.05). During the treatment,the incidences of decreased white blood cell counts,decreased platelet counts, gastrointestinal reactions and anemia were 20.00%, 5.71%, 20.00% and14.29% respectively in the observation group and were 34.29%,22.86%,40.00% and 34.29% respectively in the control group,di

关 键 词：非小细胞肺癌 化疗 六君祛痰解毒汤 血管内皮生长因子 卡氏评分 

分 类 号：R734.2[医药卫生—肿瘤]