Anti-inflammatory sesquiterpene polyol esters from the stem and branch of Tripterygium wilfordii  

作　　者：HU Yalin XU Tianqi YIN Wenjing CHENG Huaiyu ZHANG Xia LIU Ying ZHANG Yubo ZHOU Guangxiong 

机构地区：[1]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,Institute of Traditional Chinese Medicine and Natural Products,College of Pharmacy,Jinan University,Guangzhou 511436,China [2]Department of Pharmacology,School of Medicine,Guangdong Clinical Translation Center for Targeted Drug,Jinan University,Guangzhou 511436,China

出　　处：《Chinese Journal of Natural Medicines》2023年第3期233-240,共8页中国天然药物（英文版）

基　　金：the Natural Science Foundation Committee of Guangdong Province(No.32220053);the National Key R&D Program of China(No.2017YFC1703800).

摘　　要：The stem and branch extract of Tripterygium wilfordii(Celastraceae)afforded seven new dihydroagarofuran sesquiterpene polyesters[tripterysines A‒G(1‒7)]and eight known ones(8‒15).The chemical structures of these new compounds were established based on combinational analysis of HR-ESI-MS and NMR techniques.The absolute configurations of tripterysines A‒C(1‒3)and E‒G(5‒7)were determined by X-ray crystallographic analysis and circular dichroism spectra.All the compounds were screened for their inhibitory effect on inflammation through determining their inhibitory effect on nitric oxide production in LPS-induced RAW 264.7 cells and the secretion of inflammatory cytokines TNF-αand IL-6 in LPS-induced BV2 macrophages.Compound 9 exhibited significant inhibitory activity on NO production with an IC50 value of 8.77μmol·L−1.Moreover,compound 7 showed the strongest inhibitory effect with the secretion of IL-6 at 27.36%.

关 键 词：Tripterygium wilfordii Sesquiterpene polyester Tripterysine ANTI-INFLAMMATION 

分 类 号：R284.1[医药卫生—中药学]