Pollen-Inspired Photonic Barcodes with Prickly Surface for Multiplex Exosome Capturing and Screening  

作　　者：Ning Li Feika Bian Xiaowei Wei Lijun Cai Hongcheng Guu Yuanjin Zhao Luoran Shang 

机构地区：[1]Department of Rheumatology and Immunology,Institute of Translational Medicine,Nanjing Drum Tower Hospital,Schoolof Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China [2]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision,And Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,Zhejiang 325001,China [3]Shanghai Xuhui Central Hospital,Zhongshan-Xuhui Hospital,And the Shanghai Key Laboratory of Medical Epigenetics,The International Co-Laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology),Institutes of Biomedical Sciences,Fudan University,Shanghai,China

出　　处：《Research》2023年第1期111-119,共9页研究（英文）

基　　金：supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(22002018 and 21902024);the Natural Science Foundation of Jiangsu Province(BK20180408);the Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038).

摘　　要：Exosomes,which play an important role in intercellular communication,are closely related to the pathogenesis of disease.However,their effective capture and multiplex screening are still challenging.Here,inspired by the unique structure of pollens,we present novel photonic crystal(PhC)barcodes with prickly surface by hydrothermal synthesis for multiplex exosome capturing and screening.These pollen-inspired PhC barcodes are imparted with extremely high specific surface area and excellent prickly surface nanostructures,which can improve the capture rate and detection sensitivity of exosomes.As the internal periodic structures are kept during the hydrothermal synthesis process,the pollen-inspired PhC barcodes exhibit obvious and stable structural colors for identification,which enables multiplex detection of exosomes.Thus,the pollen-inspired PhC barcodes can not only effectively capture and enrich cancer-related exosomes but also support multiplex screening of exosomes with high sensitivity.These features make the prickly PhC barcodes ideal for the analysis of exosomes in medical diagnosis.

关 键 词：EXOSOME enable synthesis 

分 类 号：O43[机械工程—光学工程]