布洛芬与对乙酰氨基酚用于口腔科镇痛效果比较的Meta分析  

Meta-analysis of the analgesic effect of ibuprofen and acetaminophen in department of stomatology

作　　者：高静飞 王俐[1] 管静[1] GAO Jingfei;WANG Li;GUAN Jing(Department of Pharmacy,Women′s Hospital of Nanjing Medical University/Nanjing Maternity and Child Health Care Hospital,Nanjing 210004,China)

机构地区：[1]南京医科大学附属妇产医院/南京市妇幼保健院药学部,南京市210004

出　　处：《临床合理用药杂志》2023年第11期34-39,43,共7页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的评价布洛芬与对乙酰氨基酚用于口腔科镇痛效果比较的Meta分析。方法计算机检索Web of Science、Embase、PubMed、Cochrane Library、CNKI、维普、万方和中国生物医学文献数据库(CBM),收集布洛芬与对乙酰氨基酚在口腔科镇痛应用的随机对照试验(RCTs)。检索时限均从建库至2020年12月。按Cochrane系统评价的方法进行文献质量评价,应用RevMan 5.3软件对数据进行Meta分析。结果共纳入12项RCTs,825例患者。布洛芬组401例,对乙酰氨基酚组424例。Meta分析结果显示,在口腔科布洛芬与对乙酰氨基酚镇痛效果比较,各时间点(给药后2、4、6 h与晚间及1、2、3、4、7 d)的评分差异均无统计学意义(P>0.05)。结论在口腔科布洛芬与对乙酰氨基酚镇痛效果相当。Objective Meta-analysis of the analgesic effect of ibuprofen and acetaminophen in the department of stomatology.Methods Randomized controlled trials(RCTs)about ibuprofen vs.acetaminophen for application of analgesia in department of stomatology retrieved in databases of Web of Science,Embase,PubMed,Cochrane Library,CNKI,VIP,Wanfang data and CBMdisc.The search time limit was from the establishment of the database to December 2020.The literature quality was evaluated using the Cochrane system evaluation method.Then Meta-analysis was conducted using RevMan 5.3 software.Results A total of 12 RCTs involving 825 cases were included.There were 401 cases in ibuprofen group and 424 cases in acetaminophen group.The results of Meta-analysis showed,in the stomatology department,the analgesic effect of ibuprofen and acetaminophen had no statistical significance at all time points(2 h,4 h,6 h,evening,1 d,2 d,3 d,4 d,7 d after administration)(P>0.05).Conclusion In stomatology,ibuprofen and acetaminophen have similar analgesic effect.

关 键 词：口腔科 镇痛效果 布洛芬 对乙酰氨基酚 

分 类 号：R781[医药卫生—口腔医学]