血清乳酸脱氢酶、转化生长因子-β1在急性淋巴细胞白血病患儿中的表达及临床意义  

Expression of serum lactate dehydrogenase and transforming growth factor-β1 in children with acute lymphoblastic leukemia and their clinical significance

作　　者：陈军校 梁松 赵叶 CHEN Junxiao;LIANG Song;ZHAO Ye(Department of Pediatrics,Xianyang Hospital of Yan’an University,Xianyang 712000,Shaanxi,China;Department of Pediatrics,Xi’an Gaoxin Hospital,Xi’an 710000,Shaanxi,China)

机构地区：[1]延安大学咸阳医院儿科,陕西咸阳712000 [2]西安高新医院儿科,西安7100000

出　　处：《癌症进展》2023年第5期546-548,552,共4页Oncology Progress

摘　　要：目的探讨血清乳酸脱氢酶(LDH)、转化生长因子-β1(TGF-β1)在急性淋巴细胞白血病(ALL)患儿中的表达及临床意义。方法选取81例ALL患儿和73例健康体检儿童,分别作为ALL组和对照组。根据治疗后缓解情况将ALL患儿分为缓解组(n=39)和未缓解组(n=42),根据治疗后复发情况将ALL患儿分为复发组(n=31)和未复发组(n=50)。比较ALL组和对照组研究对象的LDH、TGF-β1水平,比较治疗后缓解组和未缓解组患儿的LDH、TGF-β1水平,比较治疗后复发组和未复发组患儿的LDH、TGF-β1水平。采用受试者工作特征(ROC)曲线及曲线下面积(AUC)分析LDH、TGF-β1对ALL的诊断价值。结果ALL组患儿LDH水平明显高于对照组,TGF-β1水平明显低于对照组,差异均有统计学意义(P﹤0.01)。缓解组患儿LDH水平明显低于未缓解组,TGF-β1水平明显高于未缓解组,差异均有统计学意义(P﹤0.01)。复发组患儿LDH水平明显高于未复发组,TGF-β1水平明显低于未复发组,差异均有统计学意义(P﹤0.01)。ROC曲线显示,LDH、TGF-β1诊断ALL的AUC分别为0.724、0.791,TGF-β1诊断ALL的灵敏度、特异度均高于LDH。结论ALL患儿中LDH表达水平升高,而TGF-β1表达水平降低,两者可为ALL的临床诊断提供参考,动态监测两者的水平变化可为ALL患儿病情及预后评估提供参考。Objective To investigate the expression of serum lactate dehydrogenase(LDH)and transforming growth factor-β1(TGF-β1)in children with acute lymphoblastic leukemia(ALL)and their clinical significance.Method A total of 81 children with ALL and 73 children with healthy physical examination were selected as ALL group and control group,respectively.According to the remission state after the treatment,children with ALL were divided into remission group(n=39)and unremission group(n=42).According to the recurrence state after the treatment,children with ALL were divided into recurrence group(n=31)and non-recurrence group(n=50).The LDH and TGF-β1 levels in the ALL group and the control group were compared.The LDH and TGF-β1 levels of children in the remission group and the unremission group after the treatment were compared.The LDH and TGF-β1 levels of children in the recurrence group and the non-recurrence group after the treatment were also compared.The diagnostic value of LDH and TGF-β1 for ALL was analyzed by using the receiver operating characteristic(ROC)curve and the area under the curve(AUC).Result The LDH level in the ALL group was significantly higher than that in the control group,and the level of TGF-β1 was significantly lower than that in the control group,and the differences were statistically significant(P<0.01).The LDH level in the remission group was significantly lower than that in the unremission group,and the TGF-β1 level was significantly higher than that in the unremission group,and the differences were statistically significant(P<0.01).The LDH level in the recurrence group was significantly higher than that in the non-recurrence group,and the level of TGF-β1 was significantly lower than that in the non-recurrence group,and the differences were statistically significant(P<0.01).The ROC curve showed that the AUC of LDH and TGF-β1 for the diagnosis of ALL were 0.724 and 0.791,respectively,and the sensitivity and specificity of TGF-β1 for the diagnosis of ALL were higher than those of LDH.Conc

关 键 词：乳酸脱氢酶 转化生长因子-Β1 急性淋巴细胞白血病 缓解 复发 

分 类 号：R733.7[医药卫生—肿瘤]