橄榄醇合成新工艺研究  

A New Synthetic Method of

作　　者：崔雪莲 高兴文 CUI Xuelian;GAO Xingwen(Guizhou Police College,Guiyang,Guizhou 550005,China;Guizhou City Vocational College,Guiyang,Guizhou 550025,China)

机构地区：[1]贵州警察学院,贵州贵阳550005 [2]贵州城市职业学院,贵州贵阳550025

出　　处：《今日药学》2023年第2期117-119,共3页Pharmacy Today

基　　金：贵州省普通高等学校青年科技人才成长项目(黔教合KY字[2022]331号)。

摘　　要：目的研究成本低廉、操作简便易控的橄榄醇合成方法以供工业化生产。方法以正己醛和乙酰乙酸甲酯为起始原料,经Knoevenagel缩合(碱催化的羟醛缩合反应)生成3-壬烯-2-酮,再与丙二酸二甲酯进行Michael加成和Claisen缩合、催化氧化等反应,合成橄榄醇。结果用氧化芳化在二甲基亚砜中用催化量的碘氧化合成了橄榄醇,总收率48.92%。结论此合成方法各步骤相对简洁易控,反应收率较高。OBJECTIVE To explore the synthesis method of olivine alcohol with low cost,simple operation and easy control for industrial production.METHODS Olivanol was synthesized from n-hexanal and methyl acetoacetate by Knoevenagel condensation to produce 3-nonen-2-one,and then Michael addition,Clausen condensation and catalytic oxidation with dimethyl malonate.RESULTS Olivine alcohol was synthesized by oxidative aromatic oxidation with catalyzed iodine in dimethyl sulfoxide,and the overall yield was 48.92%.CONCLUSION Each step of this synthetic method is relatively simple and easy to control with high yield.

关 键 词：橄榄醇 KNOEVENAGEL缩合 MICHAEL加成 Claisen缩合 催化氧化 合成 

分 类 号：R914.5[医药卫生—药物化学]