硫酸羟氯喹、地塞米松、转移因子治疗口腔扁平苔藓的临床效果  

Hydroxychloroquine sulfate,dexamethasone,and transfer factor for patients with oral lichen planus

作　　者：石婉莹 程国振 杜兴俊 Shi Wanying;Cheng Guozhen;Du Xingjun(Department of Pharmacy,Mengyin County People's Hospital,Linyi 276200,China;Department of Clinical Pharmacy,Mengyin County People's Hospital,Linyi 276200,China;Department of Stomatology,Mengyin County People's Hospital,Linyi 276200,China)

机构地区：[1]蒙阴县人民医院药学部,临沂276200 [2]蒙阴县人民医院临床药学科,临沂276200 [3]蒙阴县人民医院口腔科,临沂276200

出　　处：《国际医药卫生导报》2023年第8期1090-1094,共5页International Medicine and Health Guidance News

基　　金：山东省医药卫生科技发展计划项目(2020WSA0203)。

摘　　要：目的探讨硫酸羟氯喹、地塞米松、转移因子(TF)治疗口腔扁平苔藓(OLP)的临床效果。方法选取蒙阴县人民医院2018年1月至2022年1月收治的180例OLP患者进行随机对照试验,采用随机数字表法将其分为观察组和对照组,各90例。观察组男41例,女49例,年龄(48.96±5.73)岁。对照组男39例,女51例,年龄(49.13±5.64)岁。对照组采用硫酸羟氯喹、地塞米松治疗,观察组在对照组的基础上给予TF治疗。比较两组治疗效果、视觉模拟评分(VAS)、糜烂面积、亚硝酸根离子(NO_(2)^(-))、白细胞介素(IL)-10、IL-17、γ干扰素(IFN-γ)、免疫功能[CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)]和不良反应。采用t检验和χ^(2)检验。结果观察组治疗有效率为95.56%(86/90),高于对照组的85.56%(77/90)(P<0.05)。治疗后,观察组VAS、网纹-糜烂-溃疡评分量表(REU)评分、糜烂面积均低于对照组[(0.64±0.15)分比(1.21±0.23)分、(0.78±0.16)分比(1.33±0.27)分、(1.52±0.23)cm^(2)比(1.74±0.27)cm^(2),均P<0.05]。治疗后,观察组NO_(2)^(-)、IL-17、IL-10均低于对照组[(10.31±1.65)μmol/L比(13.89±1.44)μmol/L、(0.18±0.06)ng/L比(0.31±0.09)ng/L、(8.67±1.83)pg/L比(12.01±1.64)pg/L,均P<0.05];观察组IFN-γ高于对照组[(12.03±2.62)pg/L比(8.52±2.12)μmol/L,P<0.05]。治疗后,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于对照组[(56.16±5.71)%比(51.73±5.20)%、(38.56±3.97)%比(36.21±3.74)%、(1.46±0.27)比(1.32±0.25),均P<0.05];观察组CD8^(+)为(26.26±3.20)%,低于对照组的(27.68±3.39)%(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论联合硫酸羟氯喹、地塞米松、TF治疗OLP临床疗效良好,可有效调节患者唾液中NO_(2)^(-)水平,改善免疫功能和炎性反应,缓解疼痛感。To explore the clinical effect of hydroxychloroquine sulfate,dexamethasone,and transfer factor(TF)for patients with oral lichen planus(OLP).Methods A total of 180 patients with OLP treated in Mengyin County People's Hospital from January 2018 to January 2022 were selected for the random control trial.They were divided into an observation group and a control group by the random number table method,with 90 cases in each group.There were 41 males and 49 females in the observation group;they were(48.96±5.73)years old.There were 39 males and 51 females in the control group;they were(49.13±5.64)years old.The control group were treated with hydroxychloroquine sulfate and dexamethasone,and the observation group with hydroxychloroquine sulfate,dexamethasone,and TF.The curative effects,scores of Visual Analogue Scale(VAS),erosion areas,levels of nitrite ion(NO_(2)^(-)),inflammatory factors[interleukin-10(IL-10),interleukin-17(IL-17),and interferon-γ(IFN-γ)],immune function(CD3^(+),CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)),and adverse reactions were compared between the two groups.t andχ^(2) tests were applied.Results The treatment efficacy of the observation group was higher than that of the control group[95.56%(86/90)vs.85.56%(77/90);P<0.05].After the treatment,the scores of VAS and Reticulation-Erosion-Ulcer Scale(REU)and the vesicular area in the observation group were lower than those in the control group[(0.64±0.15)vs.(1.21±0.23),(0.78±0.16)vs.(1.33±0.27),and(1.52±0.23)cm^(2) vs.(1.74±0.27)cm^(2);all P<0.05].After the treatment,the levels of NO_(2)^(-),IL-17,and IL-10 in the observation group were lower than those in the control group[(10.31±1.65)μmol/L vs.(13.89±1.44)μmol/L,(0.18±0.06)ng/L vs.(0.31±0.09)ng/L,and(8.67±1.83)pg/L vs.(12.01±1.64)pg/L;all P<0.05];the IFN-γlevel in the observation group was higher than that in the control group[(12.03±2.62)pg/L vs.(8.52±2.12)μmol/L;P<0.05].After the treatment,the CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the observation group were higher than those in the con

关 键 词：口腔扁平苔藓 转移因子 硫酸羟氯喹 地塞米松 一氧化氮 白细胞介素-17 

分 类 号：R781[医药卫生—口腔医学]