Progress in organocatalytic asymmetric (4+3) cycloadditions for the enantioselective construction of seven-membered rings  

作　　者：Wei Tan Jia-Yi Zhang Cong-Hui Gao Feng Shi 

机构地区：[1]Research Center of Chiral Functional Heterocycles,School of Chemistry and Materials Science,Jiangsu Normal University,Xuzhou 221116,China [2]School of Petrochemical Engineering,Changzhou University,Changzhou 213164,China [3]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China

出　　处：《Science China Chemistry》2023年第4期966-992,共27页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(22125104,21831007);the Natural Science Foundation of Jiangsu Province(BK20210916);the High Education Natural Science Foundation of Jiangsu Province(21KJB150009)。

摘　　要：Chiral seven-membered ring systems such as seven-membered carbocycles and heterocycles are widely found in natural products and pharmaceuticals.Therefore,the catalytic enantioselective construction of such frameworks has evoked considerable interest in the field of chemistry.Among the various approaches,organocatalytic asymmetric(4+3)cycloadditions are highly effective for the enantioselective construction of seven-membered rings.Over the past two decades,substantial efforts have been devoted to this field and chemists have developed various organocatalytic asymmetric(4+3)cycloadditions.This review summarizes the progress in organocatalytic asymmetric(4+3)cycloadditions from 2003 to early 2022 and provides insights into challenging issues faced in this research field,enabling the future development of this field.

关 键 词：ORGANOCATALYSIS (4+3)cycloaddition seven-membered rings four-atom building blocks 

分 类 号：O626[理学—有机化学]