奥美拉唑注射液联合肠内营养支持治疗急性胰腺炎患者的效果  

Effect of omeprazole injection combined with enteral nutrition support on patients with acute pancreatitis

作　　者：张琪 赵燕超 Zhang Qi;Zhao Yanchao(Department of Gastroenterology,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,China)

机构地区：[1]徐州医科大学附属医院消化内科,徐州221002

出　　处：《国际医药卫生导报》2023年第7期978-982,共5页International Medicine and Health Guidance News

基　　金：徐州市科技项目(KC21185)。

摘　　要：目的探讨奥美拉唑注射液联合肠内营养支持治疗对急性胰腺炎患者症状改善及预后的影响。方法本文为随机对照试验。选取2020年1月至2022年1月徐州医科大学附属医院收治的96例急性胰腺炎患者,采用随机数字表法分为A组、B组和C组,各32例。A组男16例、女16例,年龄(46.89±7.58)岁;B组男17例、女15例,年龄(45.85±6.99)岁;C组男18例、女14例,年龄(45.02±7.74)岁。C组采用常规综合疗法,B组在C组基础上采用肠内营养支持治疗,A组在B组基础上给予奥美拉唑注射液。对比3组患者治疗效果,临床症状改善时间,治疗前后血清淀粉酶(AMS)、白细胞计数(WBC),预后。采用单因素方差分析、SNK-q检验、配对t检验、χ^(2)检验、秩和检验。结果A组总有效率[93.75%(30/32)]高于B组[75.00%(24/32)]、C组[62.50%(20/32)],差异有统计学意义(χ^(2)=4.857,P=0.032)。A组腹痛缓解时间、排气恢复时间、AMS恢复时间及住院时间[(4.63±0.63)d、(5.91±1.01)d、(5.08±0.78)d、(9.87±1.22)d]均短于B组[(6.58±0.91)d、(6.89±1.23)d、(8.21±1.49)d、(11.59±1.89)d]、C组[(8.56±1.54)d、(8.54±1.55)d、(9.28±1.65)d、(13.55±2.32)d],差异均有统计学意义(F=67.971、22.662、54.332、20.555,均P<0.001)。治疗后,A组AMS、WBC水平[(68.75±21.28)U/L、(8.86±1.27)×10^(9)/L]均低于B组[(118.83±38.92)U/L、(10.02±2.13)×10^(9)/L]、C组[(125.74±39.74)U/L、(13.74±2.38)×10^(9)/L],差异均有统计学意义(F=8.741、2.965,均P<0.05)。A组预后不良发生率[12.50%(4/32)]与B组[15.63%(5/32)]、C组[18.75%(6/32)]比较,差异无统计学意义(χ^(2)=0.258,P=0.784)。结论在急性胰腺炎治疗中,奥美拉唑注射液联合肠内营养支持治疗能够促进患者相关指标较快恢复,改善临床症状,缩短住院时长,值得进一步研究及推广。Objective To investigate the effect of omeprazole injection combined with enteral nutrition support on the symptom improvement and prognosis in patients with acute pancreatitis.Methods It was a randomized controlled trial.A total of 96 patients with acute pancreatitis admitted in Affiliated Hospital of Xuzhou Medical University from January 2020 to January 2022 were divided into group A,group B,and group C by the random number table method with 32 patients in each group.There were 16 males and 16 females in group A,with an age of(46.89±7.58)years old;there were 17 males and 15 females in group B,with an age of(45.85±6.99)years old;there were 18 males and 14 females in group C,with an age of(45.02±7.74)years old.Group C received conventional comprehensive therapy,group B received enteral nutrition support therapy on the basis of group C,and group A received omeprazole injection on the basis of group B.The therapeutic effect,clinical symptom improvement time,serum amylase(AMS)and white blood cell count(WBC)before and after treatment,and prognosis were compared among the three groups.One-way analysis of variance,SNK-q test,paired t test,χ^(2)test,and rank sum test were used.Results The total effective rate of group A[93.75%(30/32)]was higher than those of group B[75.00%(24/32)]and group C[62.50%(20/32)],with a statistically significant difference(χ^(2)=4.857,P=0.032).The abdominal pain relief time,exhaust recovery time,AMS recovery time,and length of hospital stay in group A[(4.63±0.63)d,(5.91±1.01)d,(5.08±0.78)d,and(9.87±1.22)d]were shorter than those in group B[(6.58±0.91)d,(6.89±1.23)d,(8.21±1.49)d,and(11.59±1.89)d]and group C[(8.56±1.54)d,(8.54±1.55)d,(9.28±1.65)d,and(13.55±2.32)d],with statistically significant differences(F=67.971,22.662,54.332,and 20.555;all P<0.001).After treatment,the levels of AMS and WBC in group A[(68.75±21.28)U/L and(8.86±1.27)×10^(9)/L]were lower than those in group B[(118.83±38.92)U/L and(10.02±2.13)×10^(9)/L]and group C[(125.74±39.74)U/L and(13.74±2.38)×10^(

关 键 词：急性胰腺炎 奥美拉唑注射液 肠内营养支持 预后 

分 类 号：R576[医药卫生—消化系统]