SLP-2和ELK1在甲状腺乳头状癌中的表达及临床意义  

Expression and Clinical Significance of SLP-2 and ELK1 in Thyroid Papillary Carcinoma

作　　者：高飞[1,2] 郭梦凡 丁成龙 田爽 李舟 GAO Fei;GUO Mengfan;DING Chenglong(Jiamusi University,Jiamusi City,Heilongjiang Province 154002)

机构地区：[1]佳木斯大学,黑龙江省佳木斯市154002 [2]佳木斯大学附属第一医院

出　　处：《医学理论与实践》2023年第8期1269-1271,1275,共4页The Journal of Medical Theory and Practice

基　　金：黑龙江省卫生健康委科研课题(20210101040041)。

摘　　要：目的:探讨SLP-2和ELK1在甲状腺乳头状癌(PTC)中的表达及临床意义。方法:选取60例PTC组织作为实验组,60例癌旁组织作为对照组,应用免疫组织化学方法检测两组SLP-2和ELK1的表达率,并结合临床病理特征进行相关性分析。结果:SLP-2和ELK1在癌组织中阳性表达率均高于癌旁组织;Spearman相关性检验显示二者蛋白表达在PTC癌组织中呈正相关;二者表达均与肿瘤大小、临床分期、淋巴结转移及浸润程度等临床病理特征相关。结论:SLP-2和ELK1可能与甲状腺乳头状癌的发生、发展相关,可为甲状腺乳头状癌的诊断及治疗提供新依据及方向。Objective:To investigate the expression and clinical significance of SLP-2 and ELK1 in thyroid papillary carcinoma(PTC).Methods:60 cases of PTC tissues were selected as the experimental group and 60 cases of adjacent tissues as the control group.The expression rates of SLP-2 and ELK1 in the two groups were detected by immunohistochemical method,and the correlation analysis was carried out bases on clinocopathological characteristics.Results:The positive expression rates of SLP-2 and ELK1 in caner tissues were higher than those in adjacent tissues.Spearman correlation test showed that two proteins were positively correlated in PTC cancer tissues.Both expression were correlated with clinicopathologic features such as tumor size,clinical stage,lymph node metastasis and degree of invasion.Conclusion:SLP-2 and ELK1 may be related to the occurrence and development of thyroid papillary carcinoma,which can provide a new basis and direction for the diagnosis and treatment of thyroid papillary carcinoma.

关 键 词：甲状腺乳头状癌 SLP-2 ELK1 免疫组化 临床病理特征 

分 类 号：R736.1[医药卫生—肿瘤]