非霍奇金淋巴瘤患者HO-1、TPS及β2-MG表达水平及其与预后的关系分析  

Analysis of expression levels of HO-1,TPS and β2-MG in patients with non-Hodgkin lymphoma and their relationship with prognosis

作　　者：王梅 王梅玉 柳韶真 姬宏莉 张利娟 闫春梅 WANG Mei;WANG Mei-yu;LIU Shao-Zhen;JI Hong-Li;ZHANG Li-Juan;YAN Chun-Mei(Hematology and Oncology,988 Hospital of Joint Logistics Support Force of PLA,Zhengzhou 450000,China;Geriatrics Department,988 Hospital of Joint Logistic Support Force of PLA,Zhengzhou 450000,China;Department of General Practice,988 Hospital of Joint Logistic Support Force of PLA,Zhengzhou 450000,China)

机构地区：[1]中国人民解放军联勤保障部队第九八八医院血液肿瘤科,郑州450000 [2]中国人民解放军联勤保障部队第九八八医院老年病科,郑州450000 [3]中国人民解放军联勤保障部队第九八八医院全科医学科,郑州450000

出　　处：《医药论坛杂志》2023年第3期17-22,共6页Journal of Medical Forum

摘　　要：目的分析非霍奇金淋巴瘤(NHL)患者血红素氧合酶1(HO-1)、组织多肽特异抗原(TPS)及β2-微球蛋白(β2-MG)表达水平及其与预后的关系分析。方法采用免疫组化法检测85例NHL患者组织标本(NHL组)和同期收治的33例淋巴结反应性增生患者组织标本(对照组)检测HO-1、β2-M表达,采用ELISA法检测血清TPS表达,分析HO-1、TPS及β2-MG表达与NHL患者临床病理特征的关系,并探讨三者表达与NHL患者预后的关系。结果HO-1在NHL组织中阳性表达率为65.88%(56/85),显著高于在淋巴结反应性增生组织中阳性表达率12.12%(4/33)(P<0.05);β2-MG在NHL组织中阳性表达率为71.76%(61/85),显著高于在淋巴结反应性增生组织中阳性表达率24.24%(8/33)(P<0.05);TPS在NHL组织中表达水平为(100.49±31.52)U/L,阳性表达率为62.35%(53/85),分别显著高于在淋巴结反应性增生组织中表达水平(58.71±26.45)U/L和阳性表达率30.30%(10/33)(P<0.05);HO-1、TPS及β2-MG在Ⅲ、Ⅳ期NHL患者中的阳性表达率显著高于Ⅰ、Ⅱ期(P<0.05),在有B症状NHL患者中的阳性表达率显著高于无B症状(P<0.05),在有骨髓侵犯NHL患者中的阳性表达率显著高于无骨髓侵犯(P<0.05),HO-1、TPS及β2-MG表达水平在不同性别、年龄、LDH水平、IPI评分NHL患者中差异不具有统计学意义(P>0.05);HO-1、TPS及β2-MG阳性表达患者3年生存率显著低于阴性表达患者(P<0.05);Cox多因素回归分析显示,B症状、骨髓侵犯是影响NHL患者预后的独立危险因素(P<0.05)。结论HO-1、TPS及β2-MG在NHL中阳性表达率均较高,其表达水平可能与NHL进展及预后有关。Objective To analyze the expression levels of heme oxygenase 1(HO-1),tissue polypeptide specific antigen(TPS)andβ2-microglobulin(β2-MG)in patients with non-Hodgkin lymphoma(NHL)and their relationship with prognosis.Methods Immunohistochemical method was used to detect the expressions of HO-1 andβ2-M of tissue samples of 85 NHL patients(NHL group)and 33 patients with lymphoid reactive hyperplasia admitted to the same period(control group).ELISA method was used to detect the expression of serum TPS.The relationship between expressions of HO-1,TPS andβ2-MG and clinicopathological characteristics of NHL patients was analyzed,and the relationship between the three expressions and the prognosis of NHL patients was explored.Results The positive expression rate of HO-1 in NHL tissue was significantly higher than that in lymphoid reactive hyperplasia tissue[65.88%(56/85)vs 12.12%(4/33)](P<0.05).The positive expression rate ofβ2-MG in NHL tissue was significantly higher than that in lymphoid reactive hyperplasia tissue[71.76%(61/85)vs 24.24%(8/33)](P<0.05).The expression level of TPS and positive expression rate in NHL tissue were significantly higher than those in lymphoid reactive hyperplasia tissue[(100.49±31.52)U/L vs(58.71±26.45)U/L,62.35%(53/85)vs 30.30%(10/33)](P<0.05).The positive expression rates of HO-1,TPS andβ2-MG in patients with stage III or IV NHL were significantly higher than those in patients with stage I or II(P<0.05),and the positive expression rates of NHL patients with B symptom were significantly higher than those of patients without B symptom(P<0.05),and the positive expression rates in NHL patients with bone marrow invasion were significantly higher than those in patients without bone marrow invasion(P<0.05).There were no statistically significant differences in the expression levels of HO-1,TPS andβ2-MG among NHL patients with different gender,age,LDH level and IPI score(P>0.05).The 3-year survival rate of patients with positive expressions of HO-1,TPS andβ2-MG was significantly lower th

关 键 词：血红素氧合酶1 组织多肽特异抗原 β2-微球蛋白 非霍奇金淋巴瘤 预后 

分 类 号：R733[医药卫生—肿瘤]