对比MR 3D及2D测量法与宫颈癌分期及病理特征的相关性研究  

Comparative study of 3D and 2D measurement in MR assessment of cervical cancer:correlation with clinical staging and histopathology findings

作　　者：张洁 詹润根 张亚利 张怡 于向荣 王国杰[4] 杨乐伟[5] ZHANG Jie;ZHAN Rungen;ZHANG Yali;ZHANG Yi;YU Xiangrong;WANG Guojie;YANG Lewei(Department of Radiology,Zhuhai People’s Hospital,Zhuhai,Guangdong Province 519000,China;Yulin Suide Xindian Health Center,Yulin,Shaanxi Province 718000,China;Department of Oncology,Zhuhai People’s Hospital,Zhuhai,Guang dong Province 519000,China;Department of Radiology,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhongshan,Guang dong Province 528406,China;Department of Oncology,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhong shan,Guangdong Province 528406,China)

机构地区：[1]珠海市人民医院放射科,广东珠海519000 [2]榆林市绥德县辛店卫生院,陕西榆林718000 [3]珠海市人民医院肿瘤科,广东珠海519000 [4]中山大学附属第五医院放射科,广东中山528406 [5]中山大学附属第五医院肿瘤科,广东中山528406

出　　处：《实用放射学杂志》2023年第3期420-423,共4页Journal of Practical Radiology

基　　金：珠海市科技计划医疗卫生项目(一般项目)(20191208E030031)。

摘　　要：目的探讨2D直径测量法与3 D体积测量法在宫颈癌治疗前MR测量评价中的临床实用性,对比2D及3 D测量结果与宫颈癌临床分期及病理特征的关系。方法选取经病理证实宫颈癌患者44例(腺癌7例,鳞癌37例),行常规MR、动态对比增强磁共振(DCE-MR)和扩散加权成像(DWI)扫描。对比2D与3 D测量结果在正常宫颈组织与宫颈癌之间的差异。比较2D及3D测量结果与宫颈癌病理分级、临床分期的关系。结果宫颈癌2D及3D测量法测得信号数值差异无统计学意义(P>0.05);3D测量法测得肿瘤体积及2D测量法测得部分数值(最大横断面长径、最大上下径)在宫颈癌不同病理分级间的差异有统计学意义(P<0.05);3D测量法测得肿瘤体积及2D测量法测得部分数值(最大横断面短径、最大上下径)在不同临床分期间的差异有统计学意义(P<0.05)。结论3D体积测量法可用于宫颈癌MR测量,3D测量法对于区分宫颈癌病理分化程度及分期优于2D测量法。应用3D体积测量法可以更全面、准确地对宫颈癌进行治疗前MR评估,有望更多应用于宫颈癌术前评估、疗效评估及3D影像组学分析等研究中。Objective To assess the clinical utility of 3 D volume measurement and 2D diameter measurement in MR assessment of the pre-treatment cervical cancer,to investigate the correlation between outcomes of measurement and the staging of tumor,histopathological feature in cervical cancer.Methods There were 44 patients with pathologically confirmed cervical cancer(37 squamous cell carcinoma,7 adenomatous carcinoma)included in the study.All patients underwent scan by both conventional MR scan,dynamic contrast enhanced magnetic resonance(DCE-MR)and diffusion weighted imaging(DWI)scans.The outcomes of measurement between 3 D and 2D were compared between normal cervical tissue and cervical cancer.The outcomes of measurement between 3 D and 2D were compared associated with pathological grade and clinical stage of cervical cancer.Results No difference found between the outcomes of 3 D and 2D measurement of cervical cancer(P>0.05).The outcomes between 3 D and 2D measurement tumor volume(maximum length of cross-section,maximum diameter of upper and lower)among different pathological grade of cervical cancer had statistical significance(P<0.05).Further analysis showed that the outcomes between 3D and 2D measurement tumor volume(maximum length of cross-section,maximum diameter of upper and lower)among different clinical stage of cervical cancer had statistical difference(P<0.05).Conclusion 3 D volume measurement can be used in MR measurement of cervical cancer,and it is preferred to 2D measurement correlated with the pathological grading and clinical stage of cervical cancer.It is more comprehensive and accurate in pre-treatment MR assessment using 3 D volume measurement of cervical cancer.3 D volume measurement can be applied to preoperative MR assessment,therapy response and 3 D radiomics analysis for cervical cancer.

关 键 词：宫颈癌 肿瘤分期 磁共振成像 

分 类 号：R737.33[医药卫生—肿瘤] R445.2[医药卫生—临床医学]